Gene Symbol | ATP8B3 |
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Entrez Gene | 148229 |
Alt Symbol | ATPIK |
Species | Human |
Gene Type | protein-coding |
Description | ATPase, aminophospholipid transporter, class I, type 8B, member 3 |
Other Description | ATPase, class I, type 8B, member 3|aminophospholipid translocase ATP8B3|phospholipid-transporting ATPase IK|potential phospholipid-transporting ATPase IK|probable phospholipid-transporting ATPase IK |
Swissprots | Q8IVB8 Q96M22 Q8N4Y8 O60423 Q7Z485 |
Accessions | AAC17601 EAW69454 EAW69455 EAW69456 EAW69457 EAW69458 EAW69459 EAW69460 EAW69461 EAW69462 EAW69463 O60423 AK057452 BAB71492 AK058189 BAB71708 AK125225 BAC86088 AK125969 AW444739 AY302538 AAQ19028 BC033179 BC035162 AAH35162 BU542181 BX427831 CD365734 DA111464 DB453086 XM_006722654 XP_006722717 XM_006722655 XP_006722718 XM_006722656 XP_006722719 XM_006722657 XP_006722720 XM_011527707 XP_011526009 XM_011527708 XP_011526010 XM_011527709 XP_011526011 XM_011527710 XP_011526012 XM_011527711 XP_011526013 XM_011527712 XP_011526014 XR_936159 NM_001178002 NP_001171473 NM_138813 NP_620168 NR_047593 |
Function | P4-ATPase flippase which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. May be responsible for the maintenance of asymmetric distribution of phosphatidylserine (PS) in spermatozoa membranes. Involved in acrosome reactions and binding of spermatozoa to zona pellucida (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum {ECO:0000269|PubMed:20947505}. |
Tissue Specificity | Isoform 3 was only detected in testis. {ECO:0000269|PubMed:12880872}. |
ATP8B3 (T-14) - sc-167169 from Santa Cruz Biotechnology
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Anti-ATP8B3 antibody - N-terminal - ab156388 from Abcam
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Anti-ATP8B3 Antibody (aa56-84, APC) - LS-C212869 from LifeSpan Bioscience
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Anti-ATP8B3 Antibody (aa56-84, Azide-free, HRP) - LS-C212870 from LifeSpan Bioscience
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Anti-ATP8B3 Antibody (aa56-84, FITC) - LS-C212871 from LifeSpan Bioscience
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Anti-ATP8B3 Antibody (aa56-84) - LS-C157568 from LifeSpan Bioscience
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Anti-ATP8B3 Antibody (aa56-84, PE) - LS-C212872 from LifeSpan Bioscience
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Anti-ATP8B3 Antibody (aa56-84) - LS-C319712 from LifeSpan Bioscience
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Anti-ATP8B3 Antibody (aa56-84, AP) - LS-C212867 from LifeSpan Bioscience
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Anti-ATP8B3 Antibody (aa56-84, Biotin) - LS-C212868 from LifeSpan Bioscience
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ATP8B3 Antibody - NBP2-31912 from Novus Biologicals
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ATP8B3 Antibody - NBP2-33398 from Novus Biologicals
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Anti-ATP8B3 antibody produced in rabbit - HPA043582 from Sigma-Aldrich
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Anti-ATP8B3 antibody produced in rabbit - HPA041992 from Sigma-Aldrich
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ATP8B3-Antibody-N-term - AP20206a from Abgent, a WuXi AppTec company
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Anti -ATP8B3, NT (ATP8B3, ATP1K, FOS37502_2, Probable phospholipid-transporting ATPase IK,ATPase class I type 8B member 3) - 032306 from USBiological Life Science
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Anti -ATP8B3, NT (ATP8B3, ATP1K, FOS37502_2, Probable phospholipid-transporting ATPase IK,ATPase class I type 8B member 3) (AP) - 032306-AP from USBiological Life Science
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Anti -ATP8B3, NT (ATP8B3, ATP1K, FOS37502_2, Probable phospholipid-transporting ATPase IK,ATPase class I type 8B member 3) (APC) - 032306-APC from USBiological Life Science
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Anti -ATP8B3, NT (ATP8B3, ATP1K, FOS37502_2, Probable phospholipid-transporting ATPase IK,ATPase class I type 8B member 3) (Azide free) (HRP) - 032306-HRP from USBiological Life Science
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Anti -ATP8B3, NT (ATP8B3, ATP1K, FOS37502_2, Probable phospholipid-transporting ATPase IK,ATPase class I type 8B member 3) (Biotin) - 032306-Biotin from USBiological Life Science
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Anti -ATP8B3, NT (ATP8B3, ATP1K, FOS37502_2, Probable phospholipid-transporting ATPase IK,ATPase class I type 8B member 3) (FITC) - 032306-FITC from USBiological Life Science
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Anti -ATP8B3, NT (ATP8B3, ATP1K, FOS37502_2, Probable phospholipid-transporting ATPase IK,ATPase class I type 8B member 3) (PE) - 032306-PE from USBiological Life Science
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ATP8B3 Antibody - N-terminal region (OAAB15582) - OAAB15582 from Aviva Systems Biology
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ATP8B3 Antibody - abx031443 from Abbexa
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ATP8B3 antibody - 17099-1-AP from Proteintech Group
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