| Gene Symbol |
ATP8B3
|
| Entrez Gene |
148229
|
| Alt Symbol |
ATPIK
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ATPase, aminophospholipid transporter, class I, type 8B, member 3
|
| Other Description |
ATPase, class I, type 8B, member 3|aminophospholipid translocase ATP8B3|phospholipid-transporting ATPase IK|potential phospholipid-transporting ATPase IK|probable phospholipid-transporting ATPase IK
|
| Swissprots |
Q8IVB8 Q96M22 Q8N4Y8 O60423 Q7Z485
|
| Accessions |
AAC17601 EAW69454 EAW69455 EAW69456 EAW69457 EAW69458 EAW69459 EAW69460 EAW69461 EAW69462 EAW69463 O60423 AK057452 BAB71492 AK058189 BAB71708 AK125225 BAC86088 AK125969 AW444739 AY302538 AAQ19028 BC033179 BC035162 AAH35162 BU542181 BX427831 CD365734 DA111464 DB453086 XM_006722654 XP_006722717 XM_006722655 XP_006722718 XM_006722656 XP_006722719 XM_006722657 XP_006722720 XM_011527707 XP_011526009 XM_011527708 XP_011526010 XM_011527709 XP_011526011 XM_011527710 XP_011526012 XM_011527711 XP_011526013 XM_011527712 XP_011526014 XR_936159 NM_001178002 NP_001171473 NM_138813 NP_620168 NR_047593
|
| Function |
P4-ATPase flippase which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. May be responsible for the maintenance of asymmetric distribution of phosphatidylserine (PS) in spermatozoa membranes. Involved in acrosome reactions and binding of spermatozoa to zona pellucida (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum {ECO:0000269|PubMed:20947505}.
|
| Tissue Specificity |
Isoform 3 was only detected in testis. {ECO:0000269|PubMed:12880872}.
|