| Gene Symbol |
MAL2
|
| Entrez Gene |
114569
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mal, T-cell differentiation protein 2 (gene/pseudogene)
|
| Other Description |
MAL proteolipid protein 2|MAL2 proteolipid protein|protein MAL2
|
| Swissprots |
Q969L2 Q6ZMD9 B2R520
|
| Accessions |
CAY39329 EAW91981 EAW91982 Q969L2 AK172820 BAD18789 AK312030 BAG34967 AL117612 AY007723 AAG15576 BC012367 AAH12367 CV574204 DQ890584 ABM92201 DQ893743 ABM84669 XM_011516807 XP_011515109 NM_052886 NP_443118
|
| Function |
Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway. {ECO:0000269|PubMed:12370246}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Endomembrane system. Cytoplasm, perinuclear region. Note=Associated with lipid rafts. In polarized epithelial cells, restricted to the apical surface. In hepatocytes, as well as in polarized hepatoma Hep-G2 cells, found in the canalicular membrane, equivalent to the apical surface, beneath the canalicular actin cytoskeleton. In non- polarized Hep-G2 cells, distributed to the perinuclear region.
|
| Tissue Specificity |
Predominantly expressed in kidney, lung, and liver. Also found in thyroid gland, stomach and, at lower levels in testis and small intestine. {ECO:0000269|PubMed:11549320, ECO:0000269|PubMed:14576188}.
|