Gene Symbol | MAL2 |
---|---|
Entrez Gene | 114569 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | mal, T-cell differentiation protein 2 (gene/pseudogene) |
Other Description | MAL proteolipid protein 2|MAL2 proteolipid protein|protein MAL2 |
Swissprots | Q969L2 Q6ZMD9 B2R520 |
Accessions | CAY39329 EAW91981 EAW91982 Q969L2 AK172820 BAD18789 AK312030 BAG34967 AL117612 AY007723 AAG15576 BC012367 AAH12367 CV574204 DQ890584 ABM92201 DQ893743 ABM84669 XM_011516807 XP_011515109 NM_052886 NP_443118 |
Function | Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway. {ECO:0000269|PubMed:12370246}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Endomembrane system. Cytoplasm, perinuclear region. Note=Associated with lipid rafts. In polarized epithelial cells, restricted to the apical surface. In hepatocytes, as well as in polarized hepatoma Hep-G2 cells, found in the canalicular membrane, equivalent to the apical surface, beneath the canalicular actin cytoskeleton. In non- polarized Hep-G2 cells, distributed to the perinuclear region. |
Tissue Specificity | Predominantly expressed in kidney, lung, and liver. Also found in thyroid gland, stomach and, at lower levels in testis and small intestine. {ECO:0000269|PubMed:11549320, ECO:0000269|PubMed:14576188}. |
MAL2 CRISPR/Cas9 KO Plasmid (h) - sc-406456 from Santa Cruz Biotechnology
|
||||||||
MAL2 HDR Plasmid (h) - sc-406456-HDR from Santa Cruz Biotechnology
|
||||||||
MAL2 Double Nickase Plasmid (h) - sc-406456-NIC from Santa Cruz Biotechnology
|
||||||||
MAL2 Double Nickase Plasmid (h2) - sc-406456-NIC-2 from Santa Cruz Biotechnology
|
||||||||
MAL2 CRISPR Activation Plasmid (h) - sc-406456-ACT from Santa Cruz Biotechnology
|
||||||||
MAL2 CRISPR Activation Plasmid (h2) - sc-406456-ACT-2 from Santa Cruz Biotechnology
|
||||||||
MAL2 Lentiviral Activation Particles (h) - sc-406456-LAC from Santa Cruz Biotechnology
|
||||||||
MAL2 Lentiviral Activation Particles (h2) - sc-406456-LAC-2 from Santa Cruz Biotechnology
|
||||||||
MAL2 siRNA (h) - sc-77560 from Santa Cruz Biotechnology
|
||||||||
MAL2 shRNA Plasmid (h) - sc-77560-SH from Santa Cruz Biotechnology
|
||||||||
MAL2 shRNA (h) Lentiviral Particles - sc-77560-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU048681 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN12950 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12950 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR11344 from Sigma-Aldrich
|
||||||||
MAL2 siRNA (Human) - CRJ4358 from Cohesion Biosciences
|
||||||||
shRNA set against Human MAL2 (NM_052886.2) - SHH337127 from Creative biogene
|
||||||||
shRNA set against Human MAL2(NM_052886.2) - SHH171947 from Creative biogene
|
||||||||
MAL2 shRNA Plasmid (Human) - CHJ4358 from Cohesion Biosciences
|
||||||||
MAL2 miRNA 3'UTR clone - MiUTR1H-06027 from Creative biogene
|