Gene Symbol | AFG3L2 |
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Entrez Gene | 10939 |
Alt Symbol | SCA28, SPAX5 |
Species | Human |
Gene Type | protein-coding |
Description | AFG3-like AAA ATPase 2 |
Other Description | AFG3 ATPase family gene 3-like 2|AFG3 ATPase family member 3-like 2|AFG3-like protein 2|ATPase family gene 3, yeast|paraplegin-like protein |
Swissprots | Q6P1L0 Q9Y4W6 |
Accessions | EAX01551 EAX01552 Q9Y4W6 AK129504 BC024282 AAH24282 BC065016 AAH65016 BU786821 BX091241 DN993083 Y18314 CAB48398 XM_011525601 XP_011523903 NM_006796 NP_006787 |
Function | ATP-dependent protease which is essential for axonal development. {ECO:0000250}. |
Subcellular Location | Mitochondrion membrane {ECO:0000269|PubMed:10395799}; Multi-pass membrane protein {ECO:0000269|PubMed:10395799}. |
Tissue Specificity | Ubiquitous. Highly expressed in the cerebellar Purkinje cells. {ECO:0000269|PubMed:20208537}. |
AFG3L2 CRISPR/Cas9 KO Plasmid (h) - sc-404565 from Santa Cruz Biotechnology
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AFG3L2 HDR Plasmid (h) - sc-404565-HDR from Santa Cruz Biotechnology
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AFG3L2 Double Nickase Plasmid (h) - sc-404565-NIC from Santa Cruz Biotechnology
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AFG3L2 Double Nickase Plasmid (h2) - sc-404565-NIC-2 from Santa Cruz Biotechnology
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AFG3L2 CRISPR Activation Plasmid (h) - sc-404565-ACT from Santa Cruz Biotechnology
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AFG3L2 CRISPR Activation Plasmid (h2) - sc-404565-ACT-2 from Santa Cruz Biotechnology
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AFG3L2 Lentiviral Activation Particles (h) - sc-404565-LAC from Santa Cruz Biotechnology
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AFG3L2 Lentiviral Activation Particles (h2) - sc-404565-LAC-2 from Santa Cruz Biotechnology
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AFG3L2 siRNA (h) - sc-72464 from Santa Cruz Biotechnology
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AFG3L2 shRNA Plasmid (h) - sc-72464-SH from Santa Cruz Biotechnology
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AFG3L2 shRNA (h) Lentiviral Particles - sc-72464-V from Santa Cruz Biotechnology
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AFG3L2 RNAi - H00010939-R02 from Novus Biologicals
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MISSION® esiRNA - EHU014171 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2920 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2920 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04907 from Sigma-Aldrich
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AFG3L2 siRNA (Human) - CRH7461 from Cohesion Biosciences
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AFG3L2 - MBS8209956 from MyBioSource
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shRNA set against Human AFG3L2 (NM_006796.2) - SHH233034 from Creative biogene
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AFG3L2 shRNA Plasmid (Human) - CHH7461 from Cohesion Biosciences
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AFG3L2 miRNA 3'UTR clone - MiUTR3H-06928 from Creative biogene
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