| Gene Symbol | ENTPD5 |
|---|---|
| Entrez Gene | 957 |
| Alt Symbol | CD39L4, NTPDase-5, PCPH |
| Species | Human |
| Gene Type | protein-coding |
| Description | ectonucleoside triphosphate diphosphohydrolase 5 |
| Other Description | CD39 antigen-like 4|CD39-like 4|ER-UDPase|GDPase ENTPD5|NTPDase 5|Pcph proto-oncogene protein|UDPase ENTPD5|guanosine-diphosphatase ENTPD5|nucleoside diphosphatase|proto-oncogene CPH|uridine-diphosphatase ENTPD5 |
| Swissprots | Q96RX0 O75356 A1L4C5 |
| Accessions | EAW81149 EAW81150 EAW81151 EAW81152 EAW81153 EAW81154 EAW81155 EAW81156 O75356 AF039918 AAC39885 AF136572 AAK82950 AK025209 AY430094 AAR06666 BC020966 BC107878 BC130485 AAI30486 BC130487 AAI30488 DB017355 HQ258244 ADR82998 HQ258615 ADR83367 XM_005268221 XP_005268278 XM_005268222 XP_005268279 XM_005268224 XP_005268281 XM_006720324 XP_006720387 XM_006720325 XP_006720388 XM_006720326 XP_006720389 XM_011537385 XP_011535687 XM_011537386 XP_011535688 NM_001249 NP_001240 |
| Function | Uridine diphosphatase (UDPase) that promotes protein N- glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The nucleotide hydrolyzing preference is GDP > IDP > UDP, but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling. {ECO:0000269|PubMed:10400613}. |
| Subcellular Location | Endoplasmic reticulum {ECO:0000250}. Secreted {ECO:0000269|PubMed:10400613}. |
| Tissue Specificity | Expressed in adult liver, kidney, prostate, testis and colon. Much weaker expression in other tissues. {ECO:0000269|PubMed:9676430}. |
| Top Pathways | Purine metabolism, Pyrimidine metabolism |