ENTPD5

Gene Symbol	ENTPD5
Entrez Gene	957
Alt Symbol	CD39L4, NTPDase-5, PCPH
Species	Human
Gene Type	protein-coding
Description	ectonucleoside triphosphate diphosphohydrolase 5
Other Description	CD39 antigen-like 4|CD39-like 4|ER-UDPase|GDPase ENTPD5|NTPDase 5|Pcph proto-oncogene protein|UDPase ENTPD5|guanosine-diphosphatase ENTPD5|nucleoside diphosphatase|proto-oncogene CPH|uridine-diphosphatase ENTPD5
Swissprots	Q96RX0 O75356 A1L4C5
Accessions	EAW81149 EAW81150 EAW81151 EAW81152 EAW81153 EAW81154 EAW81155 EAW81156 O75356 AF039918 AAC39885 AF136572 AAK82950 AK025209 AY430094 AAR06666 BC020966 BC107878 BC130485 AAI30486 BC130487 AAI30488 DB017355 HQ258244 ADR82998 HQ258615 ADR83367 XM_005268221 XP_005268278 XM_005268222 XP_005268279 XM_005268224 XP_005268281 XM_006720324 XP_006720387 XM_006720325 XP_006720388 XM_006720326 XP_006720389 XM_011537385 XP_011535687 XM_011537386 XP_011535688 NM_001249 NP_001240
Function	Uridine diphosphatase (UDPase) that promotes protein N- glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The nucleotide hydrolyzing preference is GDP > IDP > UDP, but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling. {ECO:0000269|PubMed:10400613}.
Subcellular Location	Endoplasmic reticulum {ECO:0000250}. Secreted {ECO:0000269|PubMed:10400613}.
Tissue Specificity	Expressed in adult liver, kidney, prostate, testis and colon. Much weaker expression in other tissues. {ECO:0000269|PubMed:9676430}.
Top Pathways	Purine metabolism, Pyrimidine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ENTPD5 - MBS1275394 from MyBioSource Species Human Accession BC130485

ENTPD5 - MBS1278631 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC020966

ENTPD5 - MBS1267891 from MyBioSource Species Human Accession BC130487

Human ENTPD5 ORF clone(NM_001249.2) - CDCL184054 from Creative Biomart Species Human Accession NM_001249.2

Human ENTPD5 ORF Clone(NM_001249.2) - CDCL162418 from Creative Biomart Species Human Accession NM_001249.2

Human ENTPD5 Gene ORF cDNA clone in cloning vector - HG11184-M from Sino Biological Species Human

Human ENTPD5 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11184-NM from Sino Biological Species Human

Human ENTPD5 Gene ORF cDNA clone expression plasmid, N-HA tag - HG11184-NY from Sino Biological Species Human

Human ENTPD5 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11184-CF from Sino Biological Species Human

Human ENTPD5 Gene ORF cDNA clone expression plasmid, N-His tag - HG11184-NH from Sino Biological Species Human

Human ENTPD5 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11184-CM from Sino Biological Species Human

Human ENTPD5 Gene ORF cDNA clone expression plasmid, C-His tag - HG11184-CH from Sino Biological Species Human

Human ENTPD5 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11184-M-F from Sino Biological Species Human

Human ENTPD5 Gene cDNA Clone (full-length ORF Clone), expression ready, untagged - HG11184-M-N from Sino Biological Species Human Accession NM_001249.2

Human ENTPD5 Gene cDNA Clone (full-length ORF Clone), expression ready, C-HA-tagged - HG11184-CY from Sino Biological Species Human Accession NM_001249.2

Human ENTPD5 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG11184-ACR from Sino Biological Species Human

Human ENTPD5 Gene ORF cDNA clone expression plasmid - HG11184-UT from Sino Biological Species Human

Human ENTPD5 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11184-ACG from Sino Biological Species Human

Human ENTPD5 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11184-NF from Sino Biological Species Human

Human ENTPD5 ORF clone(NM_001249.2) - CDCL184054 from Creative biogene Species Human

Human ENTPD5 ORF Clone (BC020966) - CDCS409936 from Creative biogene Species Human Accession O75356

Human ENTPD5 ORF Clone (BC130487) - CDCS409937 from Creative biogene Species Human Accession O75356

Human ENTPD5 ORF Clone (BC130485) - CDCS409938 from Creative biogene Species Human Accession O75356

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