MMACHC

Gene Symbol MMACHC
Entrez Gene 25974
Alt Symbol cblC
Species Human
Gene Type protein-coding
Description methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
Other Description methylmalonic aciduria and homocystinuria type C protein
Swissprots Q9BRQ7 Q5T157 Q9Y4U1
Accessions EAX06983 Q9Y4U1 AK098537 AL080062 CAB45693 BC006122 AAH06122 BM980565 BU632364 BU839693 JF432592 ADZ15809 XM_005270724 XP_005270781 XM_011541204 XP_011539506 NM_015506 NP_056321
Function May be involved in the binding and intracellular trafficking of cobalamin (vitamin B12).
Subcellular Location Cytoplasm {ECO:0000269|PubMed:23270877}.
Tissue Specificity Widely expressed. Expressed at higher level in fetal liver. Also expressed in spleen, lymph node, thymus and bone marrow. Weakly or not expressed in peripheral blood leukocytes. {ECO:0000269|PubMed:16311595}.
Top Pathways Vitamin digestion and absorption

MMACHC CRISPR/Cas9 KO Plasmid (h) - sc-408212 from Santa Cruz Biotechnology

Category CRISPR
Species Reactivities Human

MMACHC HDR Plasmid (h) - sc-408212-HDR from Santa Cruz Biotechnology

Species Reactivities Human

MMACHC Double Nickase Plasmid (h) - sc-408212-NIC from Santa Cruz Biotechnology

Species Reactivities Human

MMACHC Double Nickase Plasmid (h2) - sc-408212-NIC-2 from Santa Cruz Biotechnology

Species Reactivities Human

MMACHC CRISPR Activation Plasmid (h) - sc-408212-ACT from Santa Cruz Biotechnology

Category CRISPR
Species Reactivities Human

MMACHC CRISPR Activation Plasmid (h2) - sc-408212-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Species Reactivities Human

MMACHC Lentiviral Activation Particles (h) - sc-408212-LAC from Santa Cruz Biotechnology

Species Reactivities Human

MMACHC Lentiviral Activation Particles (h2) - sc-408212-LAC-2 from Santa Cruz Biotechnology

Species Reactivities Human

MMACHC siRNA (h) - sc-88005 from Santa Cruz Biotechnology

Category siRNA
Species Reactivities Human

MMACHC shRNA Plasmid (h) - sc-88005-SH from Santa Cruz Biotechnology

Category siRNA
Species Reactivities Human

MMACHC shRNA (h) Lentiviral Particles - sc-88005-V from Santa Cruz Biotechnology

Category siRNA
Species Reactivities Human

MISSION® esiRNA - EHU121721 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN14417 from Sigma-Aldrich

Category ZFN Kit

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14417 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR10633 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr10633

MMACHC siRNA (Human) - CRH8625 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human MMACHC (NM_015506.2) - SHH342760 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human MMACHC(NM_015506.2) - SHG144473 from Creative biogene

Category siRNA
Species Reactivities Human

Human MMACHC siRNA - orb269127 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

MMACHC shRNA Plasmid (Human) - CHH8625 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MMACHC miRNA 3'UTR clone - MiUTR1H-06342 from Creative biogene

Species Reactivities Human
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