Gene Symbol | DYNC1LI2 |
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Entrez Gene | 1783 |
Alt Symbol | DNCLI2, LIC2 |
Species | Human |
Gene Type | protein-coding |
Description | dynein, cytoplasmic 1, light intermediate chain 2 |
Other Description | LIC-2|LIC53/55|cytoplasmic dynein 1 light intermediate chain 2|dynein light intermediate chain 2, cytosolic|dynein, cytoplasmic, light intermediate polypeptide 2 |
Swissprots | A8K6V1 B4DZP4 Q8TAT3 O43237 |
Accessions | EAW83039 EAW83040 O43237 AF035812 AAB88513 AK024863 AK095237 AK291766 BAF84455 AK295049 BAG58099 AK303031 BAG64156 AK304233 BAG65102 AL708642 BC010928 BC022934 BC025959 AAH25959 BC036633 BC069056 BM805417 BX648863 CAH56157 XR_933225 NM_001286157 NP_001273086 NM_006141 NP_006132 |
Function | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. |
Subcellular Location | Cytoplasm, cytoskeleton {ECO:0000250}. |
Top Pathways | Vasopressin-regulated water reabsorption, Phagosome, Salmonella infection |
DNCLI2 CRISPR/Cas9 KO Plasmid (h) - sc-410762 from Santa Cruz Biotechnology
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DNCLI2 HDR Plasmid (h) - sc-410762-HDR from Santa Cruz Biotechnology
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DNCLI2 Double Nickase Plasmid (h) - sc-410762-NIC from Santa Cruz Biotechnology
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DNCLI2 Double Nickase Plasmid (h2) - sc-410762-NIC-2 from Santa Cruz Biotechnology
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DNCLI2 CRISPR Activation Plasmid (h) - sc-410762-ACT from Santa Cruz Biotechnology
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DNCLI2 CRISPR Activation Plasmid (h2) - sc-410762-ACT-2 from Santa Cruz Biotechnology
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DNCLI2 Lentiviral Activation Particles (h) - sc-410762-LAC from Santa Cruz Biotechnology
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DNCLI2 Lentiviral Activation Particles (h2) - sc-410762-LAC-2 from Santa Cruz Biotechnology
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DNCLI2 siRNA (h) - sc-93178 from Santa Cruz Biotechnology
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DNCLI2 shRNA Plasmid (h) - sc-93178-SH from Santa Cruz Biotechnology
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DNCLI2 shRNA (h) Lentiviral Particles - sc-93178-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU122181 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7585 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7585 from Sigma-Aldrich
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DYNC1LI2 siRNA (Human) - CRH1239 from Cohesion Biosciences
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DYNC1LI2 - MBS8206609 from MyBioSource
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shRNA set against Human DYNC1LI2 (NM_006141.2) - SHH282145 from Creative biogene
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DYNC1LI2 shRNA Plasmid (Human) - CHH1239 from Cohesion Biosciences
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DYNC1LI2 miRNA 3'UTR clone - MiUTR1H-03055 from Creative biogene
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