ELOVL4

Gene Symbol ELOVL4
Entrez Gene 6785
Alt Symbol ADMD, CT118, ISQMR, SCA34, STGD2, STGD3
Species Human
Gene Type protein-coding
Description ELOVL fatty acid elongase 4
Other Description 3-keto acyl-CoA synthase ELOVL4|ELOVL FA elongase 4|cancer/testis antigen 118|elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4|elongation of very long chain fatty acids protein 4|very-long-chain 3-oxoacyl-CoA synthase 4
Swissprots Q86YJ1 B2R6B5 Q5TCS2 Q9H139 Q9GZR5
Accessions AAG47669 EAW48701 Q9GZR5 AF277094 AAG47668 AJ420478 AK055277 BAB70895 AK310625 AK312511 BAG35412 AY037298 AAK68639 BC038506 AAH38506 DA122864 DQ426871 DQ891229 ABM82155 HQ447854 ADQ32338 NM_022726 NP_073563
Function Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development. {ECO:0000269|PubMed:20937905}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:16036915, ECO:0000269|PubMed:20937905}; Multi- pass membrane protein {ECO:0000255}.
Tissue Specificity Expressed in the retina and at much lower level in the brain. Ubiquitous, highest expression in thymus, followed by testis, small intestine, ovary, and prostate. Little or no expression in heart, lung, liver, or leukocates. {ECO:0000269|PubMed:20937905}.
Top Pathways Fatty acid elongation

Elongation of Very Long Chain Fatty Acids Like Protein 1, ELISA Kit - MBS078856 from MyBioSource

Category ELISA Kit
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Category ELISA Kit
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Category ELISA Kit
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Elongation of Very Long Chain Fatty Acids Like Protein 1, ELISA Kit - MBS105516 from MyBioSource

Category ELISA Kit
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Category ELISA Kit
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Category ELISA Kit
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Category ELISA Kit
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Category ELISA Kit
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Category ELISA Kit
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Category ELISA Kit
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Elongation of Very Long Chain Fatty Acids Like Protein 1, ELISA Kit - MBS079768 from MyBioSource

Category ELISA Kit
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Category ELISA Kit
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Category ELISA Kit
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Category ELISA Kit
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Category ELISA Kit
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Category ELISA Kit
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Category ELISA Kit
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Category ELISA Kit
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Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human ELOVL4 ELISA Kit - E082203 from Biobool

Category ELISA Kit

Elongation of Very Long Chain Fatty Acids Protein 4 (ELOVL4), ELISA Kit - MBS9906860 from MyBioSource

Category ELISA Kit
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Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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