ELOVL4
| Gene Symbol | ELOVL4 |
|---|---|
| Entrez Gene | 6785 |
| Alt Symbol | ADMD, CT118, ISQMR, SCA34, STGD2, STGD3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ELOVL fatty acid elongase 4 |
| Other Description | 3-keto acyl-CoA synthase ELOVL4|ELOVL FA elongase 4|cancer/testis antigen 118|elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4|elongation of very long chain fatty acids protein 4|very-long-chain 3-oxoacyl-CoA synthase 4 |
| Swissprots | Q86YJ1 B2R6B5 Q5TCS2 Q9H139 Q9GZR5 |
| Accessions | AAG47669 EAW48701 Q9GZR5 AF277094 AAG47668 AJ420478 AK055277 BAB70895 AK310625 AK312511 BAG35412 AY037298 AAK68639 BC038506 AAH38506 DA122864 DQ426871 DQ891229 ABM82155 HQ447854 ADQ32338 NM_022726 NP_073563 |
| Function | Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development. {ECO:0000269|PubMed:20937905}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:16036915, ECO:0000269|PubMed:20937905}; Multi- pass membrane protein {ECO:0000255}. |
| Tissue Specificity | Expressed in the retina and at much lower level in the brain. Ubiquitous, highest expression in thymus, followed by testis, small intestine, ovary, and prostate. Little or no expression in heart, lung, liver, or leukocates. {ECO:0000269|PubMed:20937905}. |
| Top Pathways | Fatty acid elongation |
Human ELOVL4 protein fragment - ab159600 from Abcam
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ELOVL4 Antibody Blocking Peptide - LS-E4086 from LifeSpan Bioscience
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Recombinant Human ELOVL4 Protein - H00006785-Q01 from Novus Biologicals
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ELOVL4-Antibody-C-term-Blocking-Peptide - BP16326b from Abgent, a WuXi AppTec company
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ELOVL4 peptide - orb108450 from Biorbyt
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ELOVL4 Peptide - orb224213 from Biorbyt
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ELOVL4 - H00006785-Q01-10 from Acris Antibodies
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ELOVL4 - H00006785-Q01-25 from Acris Antibodies
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ELOVL4 Control Peptide - AP05307CP-N from Acris Antibodies
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ELOVL4 Control Peptide - AP09990CP-N from Acris Antibodies
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ELOVL4 Control Peptide - AP09991CP-N from Acris Antibodies
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ELOVL4 Control Peptide - AP09992CP-N from Acris Antibodies
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ELOVL4 fusion protein - ag3567 from Proteintech Group
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ELOVL4 Blocking Peptide - CBP3327 from Cohesion Biosciences
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ELOVL4 Peptide (OEEG01183) - OEEG01183 from Aviva Systems Biology
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ELOVL4, Peptide - MBS396466 from MyBioSource
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ELOVL4 Blocking Peptide - abx162189 from Abbexa
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ELOVL4 Peptide, Human - M34GP04878H from Creative Peptides
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Elongation of very long chain fatty acids protein 4 (ELOVL4), Recombinant Protein - MBS7014212 from MyBioSource
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