Cyp2f4

Gene Symbol Cyp2f4
Entrez Gene 54246
Alt Symbol CYP4502F4, Cyp2f1, Cyp2f2
Species Rat
Gene Type protein-coding
Description cytochrome P450, family 2, subfamily f, polypeptide 4
Other Description CYPIIF2|Cytochrome P450, subfamily IIF, polypeptide 1|P450-NAH-2|cytochrome P450 2F2|cytochrome P450, family 2, subfamily f, polypeptide 2|cytochrome P450, subfamily 2F, polypeptide 1|cytochrome P450-NAH-2|naphthalene dehydrogenase|naphthalene hydroxylase
Swissprots O35293
Accessions EDM07975 EDM07976 EDM07977 O35293 AF017393 AAB70259 BC070939 AAH70939 XM_006228585 XP_006228647 NM_019303 NP_062176
Function Involved in the regio- and stereoselective transformation of naphthalene to trans-1R-hydroxy-2R-glutathionyl- 1,2-dihydronaphthalene in the presence of glutathione and glutathione S-transferases. It specifically catalyzes the production of a very reactive and potentially toxic intermediate, the 2R,2S arene oxide, that is associated with necrosis of the unciliated bronchiolar epithelial cells or Clara cells in lung. {ECO:0000269|PubMed:15509722}.
Subcellular Location Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Top Pathways Metabolism of xenobiotics by cytochrome P450

Rat Cyp2f4 ORF Clone(NM_019303.1) - CDCR378597 from Creative biogene

Species Rat

Rat Cyp2f4 cDNA Clone(NM_019303.1) - CDFR011395 from Creative biogene

Species Rat
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