| Gene Symbol |
Cyp2f4
|
| Entrez Gene |
54246
|
| Alt Symbol |
CYP4502F4, Cyp2f1, Cyp2f2
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
cytochrome P450, family 2, subfamily f, polypeptide 4
|
| Other Description |
CYPIIF2|Cytochrome P450, subfamily IIF, polypeptide 1|P450-NAH-2|cytochrome P450 2F2|cytochrome P450, family 2, subfamily f, polypeptide 2|cytochrome P450, subfamily 2F, polypeptide 1|cytochrome P450-NAH-2|naphthalene dehydrogenase|naphthalene hydroxylase
|
| Swissprots |
O35293
|
| Accessions |
EDM07975 EDM07976 EDM07977 O35293 AF017393 AAB70259 BC070939 AAH70939 XM_006228585 XP_006228647 NM_019303 NP_062176
|
| Function |
Involved in the regio- and stereoselective transformation of naphthalene to trans-1R-hydroxy-2R-glutathionyl- 1,2-dihydronaphthalene in the presence of glutathione and glutathione S-transferases. It specifically catalyzes the production of a very reactive and potentially toxic intermediate, the 2R,2S arene oxide, that is associated with necrosis of the unciliated bronchiolar epithelial cells or Clara cells in lung. {ECO:0000269|PubMed:15509722}.
|
| Subcellular Location |
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
|
| Top Pathways |
Metabolism of xenobiotics by cytochrome P450
|