SPATA13

Gene Symbol SPATA13
Entrez Gene 221178
Alt Symbol ARHGEF29, ASEF2
Species Human
Gene Type protein-coding
Description spermatogenesis associated 13
Other Description APC-stimulated guanine nucleotide exchange factor 2|adenomatous polyposis coli stimulated exchange factor 2|spermatogenesis-associated protein 13
Swissprots B4DVM8 Q8TEK6 A6NF85 Q8N873 Q5VX68 B4DQB1 Q6ZML1 Q96N96 A2VEA9 J3KQH2 B4DSZ0 J3KPJ7
Accessions EAX08331 EAX08332 Q96N96 AK025586 AK055770 BAB71009 AK074117 BAB84943 AK092754 AK092759 AK097217 BAC04977 AK123031 BAG53856 AK123225 AK160371 BAD18714 AK297394 BAG59834 AK298717 BAG60873 AK299981 BAG61802 AK301149 BAG62740 AK307528 AL049335 BC043582 BC109290 AAI09291 BC109291 AAI09292 BK006072 DAA05848 BP201334 BX648244 DB221004 HG505465 HY002340 NM_001166271 NP_001159743 NM_001286792 NP_001273721 NM_001286793 NP_001273722 NM_001286794 NP_001273723 NM_001286795 NP_001273724 NM_153023 NP_694568 NR_104595
Function Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up- regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. {ECO:0000269|PubMed:17145773, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:19934221}.
Subcellular Location Cytoplasm. Cell projection, filopodium. Cell projection, lamellipodium. Cell projection, ruffle membrane. Note=Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment.
Tissue Specificity Expressed at high levels in the placenta, spleen and kidney, at moderate levels in lung, small intestine, liver, brain and heart, and at low levels in skeletal muscle. Expression is aberrantly enhanced in most colorectal tumors. {ECO:0000269|PubMed:17145773, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19893577}.

SPATA13 (N-15) - sc-84612 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
SPATA13 (N-15): sc-84612. Western blot analysis of SPATA13 expression in COLO 320DM (A) and Jurkat (B) whole cell lysates.

SPATA13 (P-19) - sc-84613 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-SPATA13 antibody - ab122701 from Abcam

Prices $443.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SPATA13 antibody (ab122701) at 1/250 dilutionLane 1 : RT-4 lysateLane 2 : U251-MG lysateLane 3 : Human plasma lysateLane 4 : Human liver lysateLane 5 : Human tonsil lysateSecondarySecondary antibody conjugated to horseradish peroxidase at 1/3000 dilution

Anti-SPATA13 antibody - ab182772 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-SPATA13 antibody (ab182772) at 1/200 dilution + HeLa cell lysate at 40 µgSecondaryGoat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution

Anti-SPATA13 antibody - ab122627 from Abcam

Prices $443.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab122627 at 1/200 dilution staining SPATA13 in paraffin-embedded Human duodenum tissue by Immunohistochemistry.

Anti-SPATA13 Antibody (aa204-232, APC) - LS-C270269 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPATA13 Antibody (aa204-232, Biotin) - LS-C270270 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPATA13 Antibody (aa204-232, AP) - LS-C270268 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPATA13 Antibody (aa204-232, FITC) - LS-C270271 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPATA13 Antibody (aa204-232, Azide-free, HRP) - LS-C270272 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPATA13 Antibody (aa204-232, PE) - LS-C270273 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPATA13 Antibody (aa211-240) - LS-C325361 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPATA13 Antibody (aa204-232) - LS-C161479 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
SPT13 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human spleen tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

SPATA13 Antibody - NBP1-90848 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SPATA13 Antibody [NBP1-90848] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells). Lane 2: NBT-II cell lysate (Rat Wistar bladder tumor cells).

SPATA13 Antibody - NBP1-90849 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: SPATA13 Antibody [NBP1-90849] - Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & cytosol.

Anti-SPATA13 antibody produced in rabbit - HPA041208 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SPATA13: <B>Cat. No. HPA041208</B>: Immunohistochemical staining of human bronchus shows strong positivity in cilia of respiratory epithelial cells.

ANTI-SPT13 (CENTER) antibody produced in rabbit - SAB1306498 from Sigma-Aldrich

Prices $326.00
Sizes 40 tst
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-SPT13 (Center): <B>Cat. No. SAB1306498</B>: SPT13 Antibody (Center) western blot analysis in HeLa cell line lysates (35 μg/lane).

SPATA13 Antibody - middle region (OAAB02918) - OAAB02918 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

SPT13-Antibody-Center - AP5504c from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
SPT13 Antibody (Center) (Cat.#AP5504c) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the SPT13 antibody detected the SPT13 protein (arrow).

SPATA13 antibody - 70R-20482 from Fitzgerald

Prices $375.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

SPATA13 antibody - 21400-1-AP from Acris Antibodies

Prices $270.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescent analysis of HepG2 cells, using SPATA13 antibody 21400-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).

Rabbit Anti-Human SPT13 (Center) - 102-16518 from RayBiotech

Host Rabbit
SPT13 Antibody (Center) (Cat# 102-16518) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the SPT13 antibody detected the SPT13 protein (arrow).

SPT13 antibody (Center) - STJ49566 from St John's Laboratory Ltd

Host Rabbit
Clonality Polyclonal
Clone RB27015

SPATA13 antibody - 21400-1-AP from Proteintech Group

Prices $279.00
Sizes con: 42 μg/150μl
Host Rabbit
Clonality Polyclonal
COLO 320 cells were subjected to SDS PAGE followed by western blot with 21400-1-AP(SPATA13 antibody) at dilution of 1:300

SPATA13 Antibody - 31130 from Signalway Antibody

Prices $189.00, $279.00
Sizes 50 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Gel: 8%SDS-PAGE Lysate: 40 µg Hela cell lysate Primary antibody: 1/200 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 5 seconds
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