SPATA13

Gene Symbol SPATA13
Entrez Gene 221178
Alt Symbol ARHGEF29, ASEF2
Species Human
Gene Type protein-coding
Description spermatogenesis associated 13
Other Description APC-stimulated guanine nucleotide exchange factor 2|adenomatous polyposis coli stimulated exchange factor 2|spermatogenesis-associated protein 13
Swissprots B4DVM8 Q8TEK6 A6NF85 Q8N873 Q5VX68 B4DQB1 Q6ZML1 Q96N96 A2VEA9 J3KQH2 B4DSZ0 J3KPJ7
Accessions EAX08331 EAX08332 Q96N96 AK025586 AK055770 BAB71009 AK074117 BAB84943 AK092754 AK092759 AK097217 BAC04977 AK123031 BAG53856 AK123225 AK160371 BAD18714 AK297394 BAG59834 AK298717 BAG60873 AK299981 BAG61802 AK301149 BAG62740 AK307528 AL049335 BC043582 BC109290 AAI09291 BC109291 AAI09292 BK006072 DAA05848 BP201334 BX648244 DB221004 HG505465 HY002340 NM_001166271 NP_001159743 NM_001286792 NP_001273721 NM_001286793 NP_001273722 NM_001286794 NP_001273723 NM_001286795 NP_001273724 NM_153023 NP_694568 NR_104595
Function Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up- regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. {ECO:0000269|PubMed:17145773, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:19934221}.
Subcellular Location Cytoplasm. Cell projection, filopodium. Cell projection, lamellipodium. Cell projection, ruffle membrane. Note=Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment.
Tissue Specificity Expressed at high levels in the placenta, spleen and kidney, at moderate levels in lung, small intestine, liver, brain and heart, and at low levels in skeletal muscle. Expression is aberrantly enhanced in most colorectal tumors. {ECO:0000269|PubMed:17145773, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19893577}.

SPATA13 CRISPR/Cas9 KO Plasmid (h) - sc-415121 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPATA13 HDR Plasmid (h) - sc-415121-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPATA13 Double Nickase Plasmid (h) - sc-415121-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPATA13 Double Nickase Plasmid (h2) - sc-415121-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPATA13 CRISPR Activation Plasmid (h) - sc-415121-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPATA13 CRISPR Activation Plasmid (h2) - sc-415121-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPATA13 Lentiviral Activation Particles (h) - sc-415121-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPATA13 Lentiviral Activation Particles (h2) - sc-415121-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPATA13 siRNA (h) - sc-76549 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SPATA13 shRNA Plasmid (h) - sc-76549-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SPATA13 shRNA (h) Lentiviral Particles - sc-76549-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU116611 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN20412 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20412 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08553 from Sigma-Aldrich

Category miRNA

SPATA13 siRNA (Human) - CRJ6495 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SPATA13 - MBS8222682 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SPATA13 (NM_153023.2) - SHH416024 from Creative biogene

Category siRNA
Species Reactivities Human

Human SPATA13 siRNA - orb276996 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SPATA13 shRNA Plasmid (Human) - CHJ6495 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SPATA13 miRNA 3'UTR clone - MiUTR4H-TG08449 from Creative biogene

Species Reactivities Human
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