| Gene Symbol | SPATA13 |
|---|---|
| Entrez Gene | 221178 |
| Alt Symbol | ARHGEF29, ASEF2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | spermatogenesis associated 13 |
| Other Description | APC-stimulated guanine nucleotide exchange factor 2|adenomatous polyposis coli stimulated exchange factor 2|spermatogenesis-associated protein 13 |
| Swissprots | B4DVM8 Q8TEK6 A6NF85 Q8N873 Q5VX68 B4DQB1 Q6ZML1 Q96N96 A2VEA9 J3KQH2 B4DSZ0 J3KPJ7 |
| Accessions | EAX08331 EAX08332 Q96N96 AK025586 AK055770 BAB71009 AK074117 BAB84943 AK092754 AK092759 AK097217 BAC04977 AK123031 BAG53856 AK123225 AK160371 BAD18714 AK297394 BAG59834 AK298717 BAG60873 AK299981 BAG61802 AK301149 BAG62740 AK307528 AL049335 BC043582 BC109290 AAI09291 BC109291 AAI09292 BK006072 DAA05848 BP201334 BX648244 DB221004 HG505465 HY002340 NM_001166271 NP_001159743 NM_001286792 NP_001273721 NM_001286793 NP_001273722 NM_001286794 NP_001273723 NM_001286795 NP_001273724 NM_153023 NP_694568 NR_104595 |
| Function | Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up- regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. {ECO:0000269|PubMed:17145773, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:19934221}. |
| Subcellular Location | Cytoplasm. Cell projection, filopodium. Cell projection, lamellipodium. Cell projection, ruffle membrane. Note=Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment. |
| Tissue Specificity | Expressed at high levels in the placenta, spleen and kidney, at moderate levels in lung, small intestine, liver, brain and heart, and at low levels in skeletal muscle. Expression is aberrantly enhanced in most colorectal tumors. {ECO:0000269|PubMed:17145773, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19893577}. |