| Gene Symbol |
Lrp6
|
| Entrez Gene |
16974
|
| Alt Symbol |
C030016K15Rik, Cd, Gw, ska26, ska<m26Jus>, skax26
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
low density lipoprotein receptor-related protein 6
|
| Other Description |
LRP-6|crooked|low density lipoprotein receptor-related protein 6; low density lipoprotein-related protein 6|low density lipoprotein-related protein 6|low-density lipoprotein receptor-related protein 6
|
| Swissprots |
O88572
|
| Accessions |
EDL10517 O88572 AF074265 AAC33007 AK021086 AK140796 BAE24482 AK162203 BAE36789 BC060704 AAH60704 CJ124877 CO042145 XM_006505657 XP_006505720 NM_008514 NP_032540
|
| Function |
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3- mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein. Endoplasmic reticulum. Note=On Wnt signaling, undergoes a cycle of caveolin- or clathrin-mediated endocytosis and plasma membrane location. Released from the endoplasmic reticulum on palmitoylation. Mono-ubiquitination retains it in the endoplasmic reticulum in the absence of palmitoylation. On Wnt signaling, phosphorylated, aggregates and colocalizes with AXIN1 and GSK3B at the plasma membrane in LRP6-signalsomes (By similarity). Chaperoned to the plasma membrane by MESD. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in early embryo. Broadly expressed throughout the embryonic ectoderm and in nascent mesoderm, and in endoderm emerging from the primitive streak. {ECO:0000269|PubMed:15142971}.
|
| Top Pathways |
Wnt signaling pathway
|