Lrp6

Gene Symbol	Lrp6
Entrez Gene	16974
Alt Symbol	C030016K15Rik, Cd, Gw, ska26, ska<m26Jus>, skax26
Species	Mouse
Gene Type	protein-coding
Description	low density lipoprotein receptor-related protein 6
Other Description	LRP-6|crooked|low density lipoprotein receptor-related protein 6; low density lipoprotein-related protein 6|low density lipoprotein-related protein 6|low-density lipoprotein receptor-related protein 6
Swissprots	O88572
Accessions	EDL10517 O88572 AF074265 AAC33007 AK021086 AK140796 BAE24482 AK162203 BAE36789 BC060704 AAH60704 CJ124877 CO042145 XM_006505657 XP_006505720 NM_008514 NP_032540
Function	Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3- mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity). {ECO:0000250}.
Subcellular Location	Membrane; Single-pass type I membrane protein. Endoplasmic reticulum. Note=On Wnt signaling, undergoes a cycle of caveolin- or clathrin-mediated endocytosis and plasma membrane location. Released from the endoplasmic reticulum on palmitoylation. Mono-ubiquitination retains it in the endoplasmic reticulum in the absence of palmitoylation. On Wnt signaling, phosphorylated, aggregates and colocalizes with AXIN1 and GSK3B at the plasma membrane in LRP6-signalsomes (By similarity). Chaperoned to the plasma membrane by MESD. {ECO:0000250}.
Tissue Specificity	Expressed in early embryo. Broadly expressed throughout the embryonic ectoderm and in nascent mesoderm, and in endoderm emerging from the primitive streak. {ECO:0000269|PubMed:15142971}.
Top Pathways	Wnt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

SignalSilence ® LRP6 siRNA II (Mouse Specific) - 9848 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

SignalSilence ® LRP6 siRNA I (Mouse Specific) - 9834 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

LRP6 CRISPR/Cas9 KO Plasmid (m) - sc-421466 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

LRP6 HDR Plasmid (m) - sc-421466-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

LRP6 Double Nickase Plasmid (m) - sc-421466-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

LRP6 Double Nickase Plasmid (m2) - sc-421466-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

LRP6 CRISPR Activation Plasmid (m) - sc-421466-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

LRP6 CRISPR Activation Plasmid (m2) - sc-421466-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

LRP6 Lentiviral Activation Particles (m) - sc-421466-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

LRP6 Lentiviral Activation Particles (m2) - sc-421466-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

LRP6 siRNA (m) - sc-37234 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

LRP6 shRNA Plasmid (m) - sc-37234-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

LRP6 shRNA (m) Lentiviral Particles - sc-37234-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

MISSION® esiRNA - EMU062691 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN34953 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND34953 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

LRP6 siRNA (Mouse) - CRM2380 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Mouse

shRNA set against Mouse Lrp6 (NM_008514.4) - SHH334075 from Creative biogene Category siRNA Species Reactivities Mouse

Mouse LRP6 siRNA - orb281856 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Mouse

LRP6 shRNA Plasmid (Mouse) - CHM2380 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Mouse

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