| Gene Symbol |
UBE2N
|
| Entrez Gene |
7334
|
| Alt Symbol |
HEL-S-71, UBC13, UBCHBEN; UBC13, UbcH-ben, UbcH13
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin-conjugating enzyme E2N
|
| Other Description |
bendless-like ubiquitin conjugating enzyme|bendless-like ubiquitin-conjugating enzyme|epididymis secretory protein Li 71|ubiquitin carrier protein N|ubiquitin-conjugating enzyme E2 N|ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)|ubiquitin-conjugating enzyme E2N (homologous to yeast UBC13)|ubiquitin-protein ligase N|yeast UBC13 homolog
|
| Swissprots |
Q53Y81 P61088
|
| Accessions |
EAW97480 EAW97481 EAW97482 P61088 AK098233 AL110140 BC000396 AAH00396 BC003365 AAH03365 BC108704 AAI08705 BI459891 BT006873 AAP35519 CB243041 D83004 BAA11675 DQ896763 ABM87762 EU176463 ABW03914 EU176466 ABW03917 FJ224354 ACI46046 XM_011538719 XP_011537021 XR_944704 XR_944705 XR_944706 XR_944707 NM_003348 NP_003339
|
| Function |
The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:19340006}. Cytoplasm {ECO:0000269|PubMed:19340006}.
|
| Top Pathways |
Ubiquitin mediated proteolysis
|
![Western Blot: Ube2N Overexpression Lysate (Adult Normal) [NBL1-17541] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Ube2N.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5925_Ube2N%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-17541-img0002.jpg)