| Gene Symbol | UBE2N |
|---|---|
| Entrez Gene | 7334 |
| Alt Symbol | HEL-S-71, UBC13, UBCHBEN; UBC13, UbcH-ben, UbcH13 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ubiquitin-conjugating enzyme E2N |
| Other Description | bendless-like ubiquitin conjugating enzyme|bendless-like ubiquitin-conjugating enzyme|epididymis secretory protein Li 71|ubiquitin carrier protein N|ubiquitin-conjugating enzyme E2 N|ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)|ubiquitin-conjugating enzyme E2N (homologous to yeast UBC13)|ubiquitin-protein ligase N|yeast UBC13 homolog |
| Swissprots | Q53Y81 P61088 |
| Accessions | EAW97480 EAW97481 EAW97482 P61088 AK098233 AL110140 BC000396 AAH00396 BC003365 AAH03365 BC108704 AAI08705 BI459891 BT006873 AAP35519 CB243041 D83004 BAA11675 DQ896763 ABM87762 EU176463 ABW03914 EU176466 ABW03917 FJ224354 ACI46046 XM_011538719 XP_011537021 XR_944704 XR_944705 XR_944706 XR_944707 NM_003348 NP_003339 |
| Function | The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:19340006}. Cytoplasm {ECO:0000269|PubMed:19340006}. |
| Top Pathways | Ubiquitin mediated proteolysis |
UBC13 CRISPR/Cas9 KO Plasmid (h) - sc-417204 from Santa Cruz Biotechnology
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UBC13 HDR Plasmid (h) - sc-417204-HDR from Santa Cruz Biotechnology
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UBC13 Double Nickase Plasmid (h) - sc-417204-NIC from Santa Cruz Biotechnology
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UBC13 Double Nickase Plasmid (h2) - sc-417204-NIC-2 from Santa Cruz Biotechnology
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UBC13 CRISPR Activation Plasmid (h) - sc-417204-ACT from Santa Cruz Biotechnology
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UBC13 CRISPR Activation Plasmid (h2) - sc-417204-ACT-2 from Santa Cruz Biotechnology
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UBC13 Lentiviral Activation Particles (h) - sc-417204-LAC from Santa Cruz Biotechnology
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UBC13 Lentiviral Activation Particles (h2) - sc-417204-LAC-2 from Santa Cruz Biotechnology
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UBC13 siRNA (h) - sc-43551 from Santa Cruz Biotechnology
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UBC13 shRNA Plasmid (h) - sc-43551-SH from Santa Cruz Biotechnology
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UBC13 shRNA (h) Lentiviral Particles - sc-43551-V from Santa Cruz Biotechnology
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UBE2N/Ubc13 RNAi - H00007334-R01 from Novus Biologicals
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MISSION® esiRNA - EHU110761 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22375 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22375 from Sigma-Aldrich
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UBE2N siRNA (Human) - CRH5014 from Cohesion Biosciences
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UBE2N - MBS8228128 from MyBioSource
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shRNA set against Human UBE2N(NM_003348.3) - SHL111342 from Creative biogene
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UBE2N shRNA Plasmid (Human) - CHH5014 from Cohesion Biosciences
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UBE2N miRNA 3'UTR clone - MiUTR1H-10954 from Creative biogene
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