| Gene Symbol |
SYT11
|
| Entrez Gene |
23208
|
| Alt Symbol |
SYT12, sytXI
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
synaptotagmin XI
|
| Other Description |
synaptotagmin 12|synaptotagmin-11
|
| Swissprots |
Q9BT88 Q5W0D4 Q96SU2 Q8IXU3 Q68CT5 Q14998
|
| Accessions |
EAW53025 EAW53026 Q9BT88 AA824539 AK026178 AK027540 BAB55186 AK074931 BAC11300 AK296378 BAG59052 AU130124 BC004291 AAH04291 BC013690 AAH13690 BC039205 AAH39205 BM801649 CA419920 CR749792 CAH18653 D38522 BAA07527 DA026743 DA239014 XM_005245014 XP_005245071 NM_152280 NP_689493
|
| Function |
May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. {ECO:0000250}.
|
| Subcellular Location |
Membrane {ECO:0000269|PubMed:12925569}; Single-pass membrane protein {ECO:0000269|PubMed:12925569}. Cell junction, synapse {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=In substantia nigra, observed in neuronal cell bodies and neurites. Found in the core of the Lewy bodies in the brain of sporadic Parkinson disease patients.
|
![Western Blot: SYT11 Overexpression Lysate (Adult Normal) [NBL1-16647] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SYT11.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7713_SYT11%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-16647-img0002.jpg)