Gene Symbol | CCL20 |
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Entrez Gene | 6364 |
Alt Symbol | CKb4, Exodus, LARC, MIP-3-alpha, MIP-3a, MIP3A, SCYA20, ST38 |
Species | Human |
Gene Type | protein-coding |
Description | chemokine (C-C motif) ligand 20 |
Other Description | C-C motif chemokine 20|CC chemokine LARC|beta chemokine exodus-1|liver and activation-regulated chemokine|macrophage inflammatory protein 3 alpha|small inducible cytokine subfamily A (Cys-Cys), member 20|small-inducible cytokine A20 |
Swissprots | Q53S51 P78556 Q99664 |
Accessions | AAN28940 AAX93214 CBX47506 EAW70877 EAW70878 P78556 BC020698 AAH20698 D17012 D86955 BAA13191 DQ891973 ABM82899 DQ896841 ABM87840 U64197 AAB61534 U77035 AAC50943 NM_001130046 NP_001123518 NM_004591 NP_004582 |
Function | Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial activity E.coli ATCC 25922 and S.aureus ATCC 29213. {ECO:0000269|PubMed:12149255}. |
Subcellular Location | Secreted. |
Tissue Specificity | Expressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, and fetal lung. Low levels seen in thymus, prostate, testis, small intestine and colon. |
Top Pathways | Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Rheumatoid arthritis, TNF signaling pathway |
Active human Macrophage Inflammatory Protein 3 alpha full length protein - ab125762 from Abcam
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Active human Macrophage Inflammatory Protein 3 alpha full length protein - ab191717 from Abcam
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Active Macrophage Inflammatory Protein 3 alpha full length protein - ab9830 from Abcam
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Active mouse Macrophage Inflammatory Protein 3 alpha full length protein - ab72992 from Abcam
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Chicken Macrophage Inflammatory Protein 3 alpha protein fragment - ab87396 from Abcam
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Human Macrophage Inflammatory Protein 3 alpha full length protein - ab175154 from Abcam
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Human Macrophage Inflammatory Protein 3 alpha full length protein - ab176046 from Abcam
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Mouse Macrophage Inflammatory Protein 3 alpha full length protein - ab50168 from Abcam
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Pig Macrophage Inflammatory Protein 3 alpha protein fragment - ab90803 from Abcam
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CCL20 / MIP-3-Alpha Antibody Blocking Peptide - LS-E10728 from LifeSpan Bioscience
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CCL20 / MIP-3-Alpha Antibody Blocking Peptide - LS-E27189 from LifeSpan Bioscience
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Recombinant Human CCL20/MIP-3 alpha Protein - NBP2-35025 from Novus Biologicals
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CCL20/MIP-3 alpha Recombinant Protein - H00006364-P01 from Novus Biologicals
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CCL20/MIP-3 alpha Recombinant Protein - P3654 from Novus Biologicals
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Recombinant Human CCL20/MIP-3 alpha Protein - NBP1-99343 from Novus Biologicals
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CCL20/MIP-3 alpha Protein - NBP1-99696 from Novus Biologicals
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Recombinant Human CCL20/MIP-3 alpha Protein - NBP1-50994 from Novus Biologicals
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MIP3 alpha Recombinant Protein (Active) - GTX48366-PRO from GeneTex
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MIP3 alpha recombinant protein - GTX65248 from GeneTex
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MIP3 alpha blocking peptide - GTX88282-PEP from GeneTex
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Recombinant Human CCL20/MIP-3 alpha - 360-MP-025 from R&D Systems
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Recombinant Human CCL20/MIP-3 alpha, CF - 360-MP-025/CF from R&D Systems
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Recombinant Mouse CCL20/MIP-3 alpha - 760-M3-025 from R&D Systems
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Recombinant Mouse CCL20/MIP-3 alpha, CF - 760-M3-025/CF from R&D Systems
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MIP 3a Protein (OPPA01596) - OPPA01596 from Aviva Systems Biology
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