| Gene Symbol | CCL20 |
|---|---|
| Entrez Gene | 6364 |
| Alt Symbol | CKb4, Exodus, LARC, MIP-3-alpha, MIP-3a, MIP3A, SCYA20, ST38 |
| Species | Human |
| Gene Type | protein-coding |
| Description | chemokine (C-C motif) ligand 20 |
| Other Description | C-C motif chemokine 20|CC chemokine LARC|beta chemokine exodus-1|liver and activation-regulated chemokine|macrophage inflammatory protein 3 alpha|small inducible cytokine subfamily A (Cys-Cys), member 20|small-inducible cytokine A20 |
| Swissprots | Q53S51 P78556 Q99664 |
| Accessions | AAN28940 AAX93214 CBX47506 EAW70877 EAW70878 P78556 BC020698 AAH20698 D17012 D86955 BAA13191 DQ891973 ABM82899 DQ896841 ABM87840 U64197 AAB61534 U77035 AAC50943 NM_001130046 NP_001123518 NM_004591 NP_004582 |
| Function | Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial activity E.coli ATCC 25922 and S.aureus ATCC 29213. {ECO:0000269|PubMed:12149255}. |
| Subcellular Location | Secreted. |
| Tissue Specificity | Expressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, and fetal lung. Low levels seen in thymus, prostate, testis, small intestine and colon. |
| Top Pathways | Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Rheumatoid arthritis, TNF signaling pathway |
MIP-3α CRISPR/Cas9 KO Plasmid (h) - sc-417242 from Santa Cruz Biotechnology
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MIP-3α HDR Plasmid (h) - sc-417242-HDR from Santa Cruz Biotechnology
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MIP-3α Double Nickase Plasmid (h) - sc-417242-NIC from Santa Cruz Biotechnology
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MIP-3α Double Nickase Plasmid (h2) - sc-417242-NIC-2 from Santa Cruz Biotechnology
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MIP-3α CRISPR Activation Plasmid (h) - sc-417242-ACT from Santa Cruz Biotechnology
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MIP-3α CRISPR Activation Plasmid (h2) - sc-417242-ACT-2 from Santa Cruz Biotechnology
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MIP-3α Lentiviral Activation Particles (h) - sc-417242-LAC from Santa Cruz Biotechnology
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MIP-3α Lentiviral Activation Particles (h2) - sc-417242-LAC-2 from Santa Cruz Biotechnology
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MIP-3α siRNA (h) - sc-43935 from Santa Cruz Biotechnology
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MIP-3α shRNA Plasmid (h) - sc-43935-SH from Santa Cruz Biotechnology
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MIP-3α shRNA (h) Lentiviral Particles - sc-43935-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU095461 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5606 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5606 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05418 from Sigma-Aldrich
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CCL20 siRNA (Human) - CRH4297 from Cohesion Biosciences
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CCL20 - MBS8201978 from MyBioSource
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shRNA set against Human CCL20 (NM_004591.2) - SHH257561 from Creative biogene
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Human CCL20 siRNA - orb264799 from Biorbyt
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CCL20 shRNA Plasmid (Human) - CHH4297 from Cohesion Biosciences
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CCL20 miRNA 3'UTR clone - MiUTR4H-TG01807 from Creative biogene
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