| Gene Symbol |
ADCY10
|
| Entrez Gene |
55811
|
| Alt Symbol |
HCA2, SAC, SACI, Sacy, hsAC
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
adenylate cyclase 10 (soluble)
|
| Other Description |
3',5'-cyclic AMP synthetase|AH-related protein|ATP pyrophosphate-lyase|adenylate cyclase type 10|germ cell soluble adenylyl cyclase|testicular soluble adenylyl cyclase (SAC)
|
| Swissprots |
O95558 Q5R329 F5GWS5 Q9NNX0 Q5R330 Q96PN6 Q8WXV4 B4DZF0
|
| Accessions |
EAW90804 EAW90805 EAW90806 EAW90807 Q96PN6 AF176813 AAF65931 AF271058 AAF74296 AF299350 AAK96045 AF331033 AAL57036 AK302884 BAG64062 AK310395 AK310531 AL035122 CAA22684 BC117366 AAI17367 BC117372 AAI17373 DB063660 XM_005245330 XP_005245387 XM_006711449 XP_006711512 XM_011509760 XP_011508062 XM_011509761 XP_011508063 XM_011509762 XP_011508064 XM_011509763 XP_011508065 XM_011509764 XP_011508066 XM_011509765 XP_011508067 XM_011509766 XP_011508068 XR_921889 NM_001167749 NP_001161221 NM_001297772 NP_001284701 NM_018417 NP_060887
|
| Function |
Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor. Involved in ciliary beat regulation. {ECO:0000269|PubMed:15659711, ECO:0000269|PubMed:17591988}.
|
| Subcellular Location |
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Note=Distributed to subcellular compartments containing cAMP targets. Found as a plasma membrane-associated protein, protein concentrated in the perinuclear region and protein colocalized with actin or tubulin.
|
| Tissue Specificity |
Weakly expressed in multiple tissues. Expressed in brain, heart, kidney, liver, lung, pancreas, peripheral blood leukocytes, placenta, skeletal muscle, stomach, thymus, airway epithelial cells, duodenum, jejunum and ileum. Very low level of expression in bone. {ECO:0000269|PubMed:11932268, ECO:0000269|PubMed:15659711, ECO:0000269|PubMed:17591988}.
|
| Top Pathways |
Circadian entrainment, cAMP signaling pathway, Purine metabolism
|
