ADCY10

Gene Symbol	ADCY10
Entrez Gene	55811
Alt Symbol	HCA2, SAC, SACI, Sacy, hsAC
Species	Human
Gene Type	protein-coding
Description	adenylate cyclase 10 (soluble)
Other Description	3',5'-cyclic AMP synthetase|AH-related protein|ATP pyrophosphate-lyase|adenylate cyclase type 10|germ cell soluble adenylyl cyclase|testicular soluble adenylyl cyclase (SAC)
Swissprots	O95558 Q5R329 F5GWS5 Q9NNX0 Q5R330 Q96PN6 Q8WXV4 B4DZF0
Accessions	EAW90804 EAW90805 EAW90806 EAW90807 Q96PN6 AF176813 AAF65931 AF271058 AAF74296 AF299350 AAK96045 AF331033 AAL57036 AK302884 BAG64062 AK310395 AK310531 AL035122 CAA22684 BC117366 AAI17367 BC117372 AAI17373 DB063660 XM_005245330 XP_005245387 XM_006711449 XP_006711512 XM_011509760 XP_011508062 XM_011509761 XP_011508063 XM_011509762 XP_011508064 XM_011509763 XP_011508065 XM_011509764 XP_011508066 XM_011509765 XP_011508067 XM_011509766 XP_011508068 XR_921889 NM_001167749 NP_001161221 NM_001297772 NP_001284701 NM_018417 NP_060887
Function	Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor. Involved in ciliary beat regulation. {ECO:0000269|PubMed:15659711, ECO:0000269|PubMed:17591988}.
Subcellular Location	Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Note=Distributed to subcellular compartments containing cAMP targets. Found as a plasma membrane-associated protein, protein concentrated in the perinuclear region and protein colocalized with actin or tubulin.
Tissue Specificity	Weakly expressed in multiple tissues. Expressed in brain, heart, kidney, liver, lung, pancreas, peripheral blood leukocytes, placenta, skeletal muscle, stomach, thymus, airway epithelial cells, duodenum, jejunum and ileum. Very low level of expression in bone. {ECO:0000269|PubMed:11932268, ECO:0000269|PubMed:15659711, ECO:0000269|PubMed:17591988}.
Top Pathways	Circadian entrainment, cAMP signaling pathway, Purine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

A cyclase X (Y-14) - sc-161293 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

A cyclase X (Q-15) - sc-161291 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-ADCY10 antibody - ab203204 from Abcam Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-ADCY10 antibody - ab82854 from Abcam Prices $379.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-ADCY10 antibody - ab85164 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ADCY10 / Adenylate Cyclase 10 Antibody (aa557-583) - LS-C156065 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-ADCY10 / Adenylate Cyclase 10 Antibody (aa564-591, APC) - LS-C232433 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ADCY10 / Adenylate Cyclase 10 Antibody (aa564-591, AP) - LS-C232432 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ADCY10 / Adenylate Cyclase 10 Antibody (aa564-591, PE) - LS-C232438 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ADCY10 / Adenylate Cyclase 10 Antibody (aa564-591, Biotin) - LS-C232434 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ADCY10 / Adenylate Cyclase 10 Antibody (aa564-591, FITC) - LS-C232435 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ADCY10 / Adenylate Cyclase 10 Antibody (aa564-591, Azide-free, HRP) - LS-C249378 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ADCY10 / Adenylate Cyclase 10 Antibody (aa564-591) - LS-C329196 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ADCY10 / Adenylate Cyclase 10 Antibody (aa396-445) - LS-C81060 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

ADCY10 Antibody - NBP1-59040 from Novus Biologicals Prices $329.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

ADCY10 Antibody - NBP1-81766 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

ADCY10 Antibody - NBP1-81765 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

ADCY10 Polyclonal Antibody - bs-3916R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-SAC antibody produced in rabbit - SAB2102074 from Sigma-Aldrich Prices $347.50, $347.50 Sizes 50 µg, 100 µl Host Rabbit Clonality Polyclonal

Anti-ADCY10 antibody produced in rabbit - HPA015243 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-ADCY10 antibody produced in rabbit - HPA017749 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

ANTI-ADCY10 (CENTER) antibody produced in rabbit - SAB1306970 from Sigma-Aldrich Prices $326.00 Sizes 40 tst Host Rabbit Clonality Polyclonal

SAC antibody - N-terminal region (ARP47447_P050) - ARP47447_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

ADCY10 Antibody - middle region (OAAB03263) - OAAB03263 from Aviva Systems Biology Prices $289.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

ADCY10-Antibody-Center - AP5862c from Abgent, a WuXi AppTec company Prices $99.00, $295.00 Sizes 80 µl, 400 µl Host Rabbit Clonality Polyclonal

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