Gene Symbol | APOOL |
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Entrez Gene | 139322 |
Alt Symbol | CXorf33, FAM121A, UNQ8193 |
Species | Human |
Gene Type | protein-coding |
Description | apolipoprotein O-like |
Other Description | AAIR8193|MICOS complex subunit MIC27|family with sequence similarity 121A |
Swissprots | Q6UXV4 Q5H9D1 Q3KNU7 |
Accessions | EAW98568 Q6UXV4 AK096909 AK130506 AY358193 AAQ88560 BC107095 BC107096 AAI07097 BE328646 BI038188 CR749250 CAH18106 XM_011530859 XP_011529161 XM_011530860 XP_011529162 XM_011530861 XP_011529163 NM_198450 NP_940852 |
Function | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. {ECO:0000269|PubMed:23704930}. |
Subcellular Location | Mitochondrion inner membrane {ECO:0000269|PubMed:23704930}; Multi-pass membrane protein {ECO:0000269|PubMed:23704930}. |
apoOL CRISPR/Cas9 KO Plasmid (h) - sc-414464 from Santa Cruz Biotechnology
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apoOL HDR Plasmid (h) - sc-414464-HDR from Santa Cruz Biotechnology
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apoOL Double Nickase Plasmid (h) - sc-414464-NIC from Santa Cruz Biotechnology
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apoOL Double Nickase Plasmid (h2) - sc-414464-NIC-2 from Santa Cruz Biotechnology
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apoOL CRISPR Activation Plasmid (h) - sc-414464-ACT from Santa Cruz Biotechnology
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apoOL CRISPR Activation Plasmid (h2) - sc-414464-ACT-2 from Santa Cruz Biotechnology
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apoOL Lentiviral Activation Particles (h) - sc-414464-LAC from Santa Cruz Biotechnology
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apoOL Lentiviral Activation Particles (h2) - sc-414464-LAC-2 from Santa Cruz Biotechnology
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apoOL siRNA (h) - sc-91074 from Santa Cruz Biotechnology
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apoOL shRNA Plasmid (h) - sc-91074-SH from Santa Cruz Biotechnology
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apoOL shRNA (h) Lentiviral Particles - sc-91074-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU022161 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3358 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3358 from Sigma-Aldrich
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APOOL siRNA (Human) - CRJ5250 from Cohesion Biosciences
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APOOL - MBS8223026 from MyBioSource
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shRNA set against Human APOOL (NM_198450.5) - SHH238714 from Creative biogene
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APOOL shRNA Plasmid (Human) - CHJ5250 from Cohesion Biosciences
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APOOL miRNA 3'UTR clone - MiUTR4H-TG00430 from Creative biogene
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