AP2M1

Gene Symbol	AP2M1
Entrez Gene	1173
Alt Symbol	AP50, CLAPM1, mu2
Species	Human
Gene Type	protein-coding
Description	adaptor-related protein complex 2, mu 1 subunit
Other Description	AP-2 complex subunit mu|AP-2 mu 2 chain|AP-2 mu chain|HA2 50 kDA subunit|adapter-related protein complex 2 mu subunit|adapter-related protein complex 2 subunit mu|adaptin-mu2|adaptor protein complex AP-2 subunit mu|adaptor-related protein complex 2 subunit mu|clathrin adaptor complex AP2, mu subunit|clathrin assembly protein complex 2 medium chain|clathrin assembly protein complex 2 mu medium chain|clathrin coat adaptor protein AP50|clathrin coat assembly protein AP50|clathrin coat-associated protein AP50|clathrin-associated/assembly/adaptor protein, medium 1|plasma membrane adaptor AP-2 50 kDa protein|plasma membrane adaptor AP-2 50kDA protein
Swissprots	D3DNT1 A6NE12 Q96CW1
Accessions	CAR81017 CBX84495 EAW78290 EAW78291 EAW78292 Q96CW1 AK057883 AK294159 BAG57482 AK295999 BAG58773 AK297578 BAH12618 AK297849 BAG60181 AK300228 BAG61996 AK304510 BAG65316 AK310409 BC004996 AAH04996 BC013796 AAH13796 BC014030 AAH14030 BI461415 BT007308 AAP35972 D63475 BAA09762 DQ892876 ABM83802 DQ895915 ABM86841 U36188 AAA93254 NM_001025205 NP_001020376 NM_004068 NP_004059
Function	Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to p
Subcellular Location	Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV. {ECO:0000250}.
Top Pathways	Huntington's disease, Endocytosis, Endocrine and other factor-regulated calcium reabsorption, Synaptic vesicle cycle

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human AP2M1 full length protein - ab40731 from Abcam Category Protein Prices $235.00 Sizes 50 µg Source E. coli Species Human

AP50 / AP2M1 Antibody Blocking Peptide - LS-E3458 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AP50 / AP2M1 Antibody Blocking Peptide - LS-E30700 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human AP2M1 Protein - H00001173-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

AP2M1 Peptide - NBP1-77028PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

AP2M1-Antibody-C-term-Blocking-Peptide - BP14642b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

AP2M1 Recombinant Protein - GTX48212-PRO from GeneTex Category Protein Prices $329.00 Sizes 50 μg Source E. coli Species Human

AP2M1 Peptide - GTX85110-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

Recombinant human AP-2 complex subunit mu protein (OPCA00342) - OPCA00342 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

AP2M1 Protein (OPPA01358) - OPPA01358 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source E. Coli

Human AP2M1 protein - orb245743 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human Assembly Protein Complex 2 protein - orb80921 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Source E.coli

Human AP2M1 protein - orb246296 from Biorbyt Category Protein Prices $213.00, $408.00, $680.00, $1,122.00, $1,777.00 Sizes 10 μg, 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human CLAPM1 protein - orb245040 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

AP2M1 peptide - orb217102 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Zebrafish, Monkey, Cat

AP2M1 Blocking Peptide - abx062433 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Chicken, Monkey, Zebrafish

AP2 complex subunit mu-1 / AP2M1 - H00001173-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

AP2 complex subunit mu-1 / AP2M1 - H00001173-P01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

AP2 complex subunit mu-1 / AP2M1 - H00001173-P01-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Species Human

AP2 complex subunit mu-1 / AP2M1 Control Peptide - AP30054CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

Recombinant Human AP2M1 - 228-10061-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source Escherichia Coli. Species Human

Recombinant Human AP2M1 - 228-10061-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Human AP2M1 - 228-10061-3 from RayBiotech Category Protein Source Escherichia Coli. Species Human

AP2M1 Peptide - 5161P from ProSci Category Peptide Species Human

AP2M1 Recombinant Protein - XW-RP3010 from ProSci Category Protein Prices $275.00 Sizes 50 µg Source E. coli Species Human

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