| Gene Symbol |
KDM3A
|
| Entrez Gene |
55818
|
| Alt Symbol |
JHDM2A, JHMD2A, JMJD1, JMJD1A, TSGA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
lysine (K)-specific demethylase 3A
|
| Other Description |
jmjC domain-containing histone demethylation protein 2A|jumonji C domain-containing histone demethylase 2A|jumonji domain containing 1|jumonji domain containing 1A|jumonji domain-containing protein 1A|lysine-specific demethylase 3A|testis-specific protein A
|
| Swissprots |
Q68D47 D6W5M3 Q8IY08 Q6N050 Q9Y4C1 Q68UT9 Q53S72
|
| Accessions |
AAY24210 EAW99453 EAW99454 EAW99455 EAW99456 Q9Y4C1 AB018285 BAA34462 AI911797 AK074314 AK125045 AK304276 BAG65137 AL832150 CAH18459 BC038297 BC156518 AAI56519 BC172547 AAI72547 BG723267 BX537674 BX640698 CAE45820 BX647271 BX647752 BX648841 BX649109 CR749581 CAH18373 DB087171 DB453517 XM_006712051 XP_006712114 XM_011532984 XP_011531286 XM_011532985 XP_011531287 XM_011532986 XP_011531288 NM_001146688 NP_001140160 NM_018433 NP_060903
|
| Function |
Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TMP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1. {ECO:0000269|PubMed:16603237}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Nuclear in round spermatids. When spermatids start to elongate, localizes to the cytoplasm where it forms distinct foci which disappear in mature spermatozoa (By similarity). {ECO:0000250}.
|