| Gene Symbol |
PDIA2
|
| Entrez Gene |
64714
|
| Alt Symbol |
PDA2, PDI, PDIP, PDIR
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein disulfide isomerase family A, member 2
|
| Other Description |
Rho GDP dissociation inhibitor gamma|pancreas-specific protein disulfide isomerase|pancreatic protein disulfide isomerase|protein disulfide isomerase A2|protein disulfide isomerase, pancreatic|protein disulfide isomerase-associated 2|protein disulfide-isomerase A2
|
| Swissprots |
B4DI27 A6ZJ64 Q13087 Q9BW95 Q6B010 Q2WGM4 Q4TT67 Q96KJ6
|
| Accessions |
AAK61223 ABO43034 CAI95586 CAI95587 CAI95588 CAO78188 EAW85838 Q13087 AK075485 BAG52154 AK124931 BAG54115 AK295383 BAG58339 AK308516 BC000537 AAH00537 BC027964 BC075029 AAH75029 BC167826 AAI67826 DA207692 U19948 AAC50401 Z84717 NM_006849 NP_006840
|
| Function |
Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins. {ECO:0000269|PubMed:19150607, ECO:0000269|PubMed:19429457}.
|
| Subcellular Location |
Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}.
|
| Tissue Specificity |
Highly expressed in pancreas (at protein level). {ECO:0000269|PubMed:19429457, ECO:0000269|PubMed:8561901, ECO:0000269|PubMed:9115635}.
|
![Western Blot: PDI Overexpression Lysate (Adult Normal) [NBP2-10396] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PDI.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2220_PDI%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10396-img0001.jpg)