NLGN3
| Gene Symbol | NLGN3 |
|---|---|
| Entrez Gene | 54413 |
| Alt Symbol | HNL3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | neuroligin 3 |
| Other Description | gliotactin homolog|neuroligin-3 |
| Swissprots | Q8NCD0 Q9NZ97 B2RBK1 Q9NZ96 Q9P248 D2X2H6 Q9NZ94 D3DVV0 Q86V51 D3DVV1 Q9NZ95 |
| Accessions | AAF71232 AAF71233 EAX05307 EAX05308 EAX05309 EAX05310 EAX05311 EAX05312 EAX05313 Q9NZ94 AB040913 BAA96004 AF217411 AAF71230 AF217412 AAF71231 AK074814 BAC11226 AK296217 BAH12284 AK299567 BAH13067 AK299669 BAH13096 AK314699 BAG37248 BC028738 AAH28738 BC051715 AAH51715 BP201014 BX641059 CAE46030 GQ489207 ADB12634 JF432393 ADZ15610 KJ534889 AHW56529 KJ534890 AHW56530 KJ534891 AHW56531 KJ534977 AHW56617 KJ535034 AHW56673 KJ535040 AHW56679 XM_005262279 XP_005262336 XM_006724662 XP_006724725 XM_006724663 XP_006724726 XM_011530974 XP_011529276 XM_011530975 XP_011529277 NM_001166660 NP_001160132 NM_018977 NP_061850 NM_181303 NP_851820 |
| Function | Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system (By similarity). {ECO:0000250}. |
| Subcellular Location | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Detected at both glutamatergic and GABAergic synapses. {ECO:0000250}. |
| Tissue Specificity | Expressed in the blood vessel walls (at protein level). Detected in throughout the brain and in spinal cord. Detected in brain, and at lower levels in pancreas islet beta cells. {ECO:0000269|PubMed:10767552, ECO:0000269|PubMed:18755801, ECO:0000269|PubMed:19926856}. |
| Top Pathways | Cell adhesion molecules (CAMs) |
neuroligin 3 CRISPR/Cas9 KO Plasmid (h) - sc-404537 from Santa Cruz Biotechnology
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neuroligin 3 HDR Plasmid (h) - sc-404537-HDR from Santa Cruz Biotechnology
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neuroligin 3 Double Nickase Plasmid (h) - sc-404537-NIC from Santa Cruz Biotechnology
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neuroligin 3 Double Nickase Plasmid (h2) - sc-404537-NIC-2 from Santa Cruz Biotechnology
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neuroligin 3 CRISPR Activation Plasmid (h) - sc-404537-ACT from Santa Cruz Biotechnology
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neuroligin 3 CRISPR Activation Plasmid (h2) - sc-404537-ACT-2 from Santa Cruz Biotechnology
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neuroligin 3 Lentiviral Activation Particles (h) - sc-404537-LAC from Santa Cruz Biotechnology
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neuroligin 3 Lentiviral Activation Particles (h2) - sc-404537-LAC-2 from Santa Cruz Biotechnology
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neuroligin 3 siRNA (h) - sc-42087 from Santa Cruz Biotechnology
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neuroligin 3 shRNA Plasmid (h) - sc-42087-SH from Santa Cruz Biotechnology
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neuroligin 3 shRNA (h) Lentiviral Particles - sc-42087-V from Santa Cruz Biotechnology
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Neuroligin 3/NLGN3 RNAi - H00054413-R01 from Novus Biologicals
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MISSION® esiRNA - EHU063861 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2441 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2441 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12477 from Sigma-Aldrich
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NLGN3 siRNA (Human) - CRJ0048 from Cohesion Biosciences
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shRNA set against Human NLGN3 (NM_018977.3) - SHH352816 from Creative biogene
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shRNA set against Human NLGN3(NM_181303.1) - SHR012540 from Creative biogene
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NLGN3 shRNA Plasmid (Human) - CHJ0048 from Cohesion Biosciences
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NLGN3 miRNA 3'UTR clone - MiUTR1H-06789 from Creative biogene
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NLGN3 miRNA 3'UTR clone - MiUTR3H-02697 from Creative biogene
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