| Gene Symbol |
Dicer1
|
| Entrez Gene |
192119
|
| Alt Symbol |
1110006F08Rik, D12Ertd7e, mKIAA0928
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
dicer 1, ribonuclease type III
|
| Other Description |
Dicer1, Dcr-1 homolog|double-strand-specific ribonuclease mDCR-1|endoribonuclease Dicer
|
| Swissprots |
Q8R418 Q8R419
|
| Accessions |
AAL84637 AAL84638 EDL18787 EDL18788 Q8R418 AB081470 BAC15765 AF430845 AAM21495 AK003494 AK033198 AK035253 BAC29002 AK129241 BAC98051 AK137929 BAE23515 BC019805 AAH19805 BC023863 BC029665 BC061198 AAH61198 BC100374 BC172621 AAI72621 XM_006515608 XP_006515671 XM_006515609 XP_006515672 XM_006515610 XP_006515673 XM_006515611 XP_006515674 NM_148948 NP_683750
|
| Function |
Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA- induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}.
|
| Tissue Specificity |
Isoform 1 is expressed in a wide variety of tissues. Isoform 2 is specifically expressed in oocytes during their growth (at protein level).
|
| Top Pathways |
MicroRNAs in cancer
|