Dicer1

Gene Symbol Dicer1
Entrez Gene 192119
Alt Symbol 1110006F08Rik, D12Ertd7e, mKIAA0928
Species Mouse
Gene Type protein-coding
Description dicer 1, ribonuclease type III
Other Description Dicer1, Dcr-1 homolog|double-strand-specific ribonuclease mDCR-1|endoribonuclease Dicer
Swissprots Q8R418 Q8R419
Accessions AAL84637 AAL84638 EDL18787 EDL18788 Q8R418 AB081470 BAC15765 AF430845 AAM21495 AK003494 AK033198 AK035253 BAC29002 AK129241 BAC98051 AK137929 BAE23515 BC019805 AAH19805 BC023863 BC029665 BC061198 AAH61198 BC100374 BC172621 AAI72621 XM_006515608 XP_006515671 XM_006515609 XP_006515672 XM_006515610 XP_006515673 XM_006515611 XP_006515674 NM_148948 NP_683750
Function Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA- induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm {ECO:0000250}.
Tissue Specificity Isoform 1 is expressed in a wide variety of tissues. Isoform 2 is specifically expressed in oocytes during their growth (at protein level).
Top Pathways MicroRNAs in cancer

Dicer CRISPR/Cas9 KO Plasmid (m) - sc-431380 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Dicer HDR Plasmid (m) - sc-431380-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Dicer Double Nickase Plasmid (m) - sc-431380-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Dicer Double Nickase Plasmid (m2) - sc-431380-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Dicer CRISPR Activation Plasmid (m) - sc-431380-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Dicer CRISPR Activation Plasmid (m2) - sc-431380-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Dicer Lentiviral Activation Particles (m) - sc-431380-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Dicer Lentiviral Activation Particles (m2) - sc-431380-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Dicer siRNA (m) - sc-40490 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

Dicer shRNA Plasmid (m) - sc-40490-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

Dicer shRNA (m) Lentiviral Particles - sc-40490-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MISSION® esiRNA - EMU059671 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN29994 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND29994 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

shRNA set against Mouse Dicer1 (NM_148948.2) - SHH278057 from Creative biogene

Category siRNA
Species Reactivities Mouse

shRNA set against Mouse Dicer1(NM_148948.2) - SHG224545 from Creative biogene

Category siRNA
Species Reactivities Mouse

DICER1 miRNA 3'UTR clone - MiUTR1M-03862 from Creative biogene

Species Reactivities Mouse
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