| Gene Symbol |
PPAP2A
|
| Entrez Gene |
8611
|
| Alt Symbol |
LLP1a, LPP1, PAP-2a, PAP2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phosphatidic acid phosphatase type 2A
|
| Other Description |
lipid phosphate phosphohydrolase 1|lipid phosphate phosphohydrolase 1a|phosphatidate phosphohydrolase type 2a|phosphatidic acid phosphatase 2a|phosphatidic acid phosphohydrolase type 2a|type-2 phosphatidic acid phosphatase alpha
|
| Swissprots |
Q17RZ4 O60457 O14494 O60463 G3XA95 B7ZKN8
|
| Accessions |
CCF77023 CCF77024 EAW54920 EAW54921 EAW54922 EAW54923 O14494 AB000888 BAA22593 AF014402 AAC16032 AF014403 AAC16033 AF017116 AAC32041 AK124204 BC008787 BC039847 AAH39847 BC117133 AAI17134 BC143281 AAI43282 BC168254 BI761588 BQ019387 CN338068 HQ448545 ADQ33024 HY063640 XM_006714724 XP_006714787 NM_003711 NP_003702 NM_176895 NP_795714 NR_103485
|
| Function |
Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). Pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system. Major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA. May control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation. It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > S-1-P > C-1-P. It's down-regulation may contribute to the development of colon adenocarcinoma. {ECO:0000269|PubMed:12909631}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Ubiquitously expressed with highest expression found in prostate. Isoform 1 is predominant in kidney, lung, placenta and liver. Isoform 2 is predominant in heart and pancreas. Found to be down-regulated in colon adenocarcinomas.
|
| Top Pathways |
Fc gamma R-mediated phagocytosis, Fat digestion and absorption, Choline metabolism in cancer, Ether lipid metabolism, Glycerolipid metabolism
|