PPAP2A

Gene Symbol	PPAP2A
Entrez Gene	8611
Alt Symbol	LLP1a, LPP1, PAP-2a, PAP2
Species	Human
Gene Type	protein-coding
Description	phosphatidic acid phosphatase type 2A
Other Description	lipid phosphate phosphohydrolase 1|lipid phosphate phosphohydrolase 1a|phosphatidate phosphohydrolase type 2a|phosphatidic acid phosphatase 2a|phosphatidic acid phosphohydrolase type 2a|type-2 phosphatidic acid phosphatase alpha
Swissprots	Q17RZ4 O60457 O14494 O60463 G3XA95 B7ZKN8
Accessions	CCF77023 CCF77024 EAW54920 EAW54921 EAW54922 EAW54923 O14494 AB000888 BAA22593 AF014402 AAC16032 AF014403 AAC16033 AF017116 AAC32041 AK124204 BC008787 BC039847 AAH39847 BC117133 AAI17134 BC143281 AAI43282 BC168254 BI761588 BQ019387 CN338068 HQ448545 ADQ33024 HY063640 XM_006714724 XP_006714787 NM_003711 NP_003702 NM_176895 NP_795714 NR_103485
Function	Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). Pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system. Major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA. May control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation. It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > S-1-P > C-1-P. It's down-regulation may contribute to the development of colon adenocarcinoma. {ECO:0000269|PubMed:12909631}.
Subcellular Location	Cell membrane; Multi-pass membrane protein.
Tissue Specificity	Ubiquitously expressed with highest expression found in prostate. Isoform 1 is predominant in kidney, lung, placenta and liver. Isoform 2 is predominant in heart and pancreas. Found to be down-regulated in colon adenocarcinomas.
Top Pathways	Fc gamma R-mediated phagocytosis, Fat digestion and absorption, Choline metabolism in cancer, Ether lipid metabolism, Glycerolipid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PPAP2A full length protein - ab160110 from Abcam Category Protein Source Wheat germ Species Human

PAP2a / PPAP2A Blocking Peptide - LS-E15507 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PAP2a / PPAP2A Antibody Blocking Peptide - LS-E15508 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PPAP2A Recombinant Protein - H00008611-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

PPAP2A Blocking Peptide - 33R-7708 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PPAP2A Blocking Peptide - 33R-2098 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PPAP2A Blocking Peptide - 33R-7596 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PPAP2A / LPP1 - H00008611-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PPAP2A / LPP1 - H00008611-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PPAP2A fusion protein - ag11596 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

PPAP2A fusion protein - Ag11615 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

PPAP2A Peptide - abx164800 from Abbexa Category Peptide Species Human, Mouse, Rat

Recombinant Phosphatidic Acid Phosphatase Type 2A (PPAP2A) - RPC733Hu01 from Cloud-clone Category Protein Source E.coli Species Human

PPAP2A Recombinant Protein Antigen - NBP2-32057PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PPAP2A-Blocking-Peptide-C-term - BP21024c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PPAP2A-Blocking-Peptide-C-term - BP21319b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PPAP2A Peptide, Human - M34GP12165H from Creative Peptides Category Peptide Source Synthetic. Species Human

Lipid phosphate phosphohydrolase 1 (PPAP2A), Recombinant Protein - MBS1000722 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Lipid phosphate phosphohydrolase 1 (PPAP2A), Recombinant Protein - MBS7026871 from MyBioSource Category Protein Prices $1,100.00, $2,085.00, $3,290.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

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