FGF1

Gene Symbol	FGF1
Entrez Gene	2246
Alt Symbol	AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-1, FGF-alpha, FGFA, GLIO703, HBGF-1, HBGF1
Species	Human
Gene Type	protein-coding
Description	fibroblast growth factor 1 (acidic)
Other Description	beta-endothelial cell growth factor|endothelial cell growth factor, alpha|endothelial cell growth factor, beta|fibroblast growth factor 1|heparin-binding growth factor 1
Swissprots	B2R5T0 P05230 Q16588 P07502 D3DQF2
Accessions	AAA52446 AAA52638 AAS99352 CAA41788 CAH18501 CAH23443 EAW61881 EAW61882 EAW61884 EAW61885 P05230 AI283639 AK289762 BAF82451 AK312301 BAG35227 BC032697 AAH32697 BG706412 DA111414 DA126618 DA189432 DA228737 DA326831 DA388578 DA389088 DA575048 DA649213 DA660034 DB092576 DB220987 DC344309 DQ655917 L01485 AAA52425 L01487 AAA52447 M13361 AAA79245 M60515 AAA51672 M60516 AAA51673 M74028 S67291 AAB29057 S67292 AAB29058 S67294 AAB29059 X51943 CAA36206 X65778 CAA46661 X65779 CAA46662 XM_005268390 XP_005268447 XM_011537607 XP_011535909 XM_011537608 XP_011535910 NM_000800 NP_000791 NM_001144892 NP_001138364 NM_001144934 NP_001138406 NM_001144935 NP_001138407 NM_001257205 NP_001244134 NM_001257206 NP_001244135 NM_001257207 NP_001244136 NM_001257208 NP_001244137 NM_001257209 NP_001244138 NM_001257210 NP_001244139 NM_001257211 NP_001244140 NM_001257212 NP_001244141 NM_033136 NP_149127 NM_033137 NP_149128
Function	Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. {ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:20145243, ECO:0000269|PubMed:8663044}.
Subcellular Location	Secreted. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytosol. Nucleus. Note=Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1 (By similarity). Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59. {ECO:0000250}.
Tissue Specificity	Predominantly expressed in kidney and brain. Detected at much lower levels in heart and skeletal muscle. {ECO:0000269|PubMed:11964394, ECO:0000269|PubMed:7504343}.
Top Pathways	Melanoma, MAPK signaling pathway, PI3K-Akt signaling pathway, Hippo signaling pathway, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

FGF-1 CRISPR/Cas9 KO Plasmid (h) - sc-416438 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

FGF-1 HDR Plasmid (h) - sc-416438-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

FGF-1 Double Nickase Plasmid (h) - sc-416438-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

FGF-1 Double Nickase Plasmid (h2) - sc-416438-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

FGF-1 CRISPR Activation Plasmid (h) - sc-416438-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

FGF-1 CRISPR Activation Plasmid (h2) - sc-416438-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

FGF-1 Lentiviral Activation Particles (h) - sc-416438-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

FGF-1 Lentiviral Activation Particles (h2) - sc-416438-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

FGF-1 siRNA (h) - sc-39444 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

FGF-1 shRNA Plasmid (h) - sc-39444-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

FGF-1 shRNA (h) Lentiviral Particles - sc-39444-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

FGF acidic/FGF1 RNAi - H00002246-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

FGF acidic/FGF1 RNAi - H00002246-R03 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

FGF acidic/FGF1 RNAi - H00002246-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU085801 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN8645 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8645 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR12816 from Sigma-Aldrich Category miRNA

FGF1 siRNA (Human) - CRH1566 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

FGF1 - MBS8217507 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human FGF1 (NM_000800.4) - SHH294361 from Creative biogene Category siRNA Species Reactivities Human

FGF1 shRNA Plasmid (Human) - CHH1566 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

FGF1 miRNA 3'UTR clone - MiUTR4H-TG03529 from Creative biogene Species Reactivities Human

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