Gene Symbol | TSN |
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Entrez Gene | 7247 |
Alt Symbol | BCLF-1, C3PO, RCHF1, REHF-1, TBRBP, TRSLN |
Species | Human |
Gene Type | protein-coding |
Description | translin |
Other Description | component 3 of promoter of RISC|recombination hotspot associated factor|recombination hotspot-binding protein|testis brain-RNA binding protein |
Swissprots | Q15631 Q5U0K7 B7Z3X8 |
Accessions | AAY14831 CAA73150 EAW95262 EAW95263 Q15631 AK091915 BAG52440 AK222868 BAD96588 AK296469 BAH12364 AK298812 BAH12875 AK307344 AK311410 AK315763 AL122099 BC002359 AAH02359 BP289175 BP309328 BT019490 AAV38297 BT019491 AAV38298 DA523145 DA772798 X78627 CAA55341 X95076 NM_001261401 NP_001248330 NM_004622 NP_004613 NR_048556 NR_048557 NR_048558 NR_048559 |
Function | DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:11801738}. Nucleus {ECO:0000269|PubMed:11801738}. |
translin CRISPR/Cas9 KO Plasmid (h) - sc-407354 from Santa Cruz Biotechnology
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translin HDR Plasmid (h) - sc-407354-HDR from Santa Cruz Biotechnology
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translin Double Nickase Plasmid (h) - sc-407354-NIC from Santa Cruz Biotechnology
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translin Double Nickase Plasmid (h2) - sc-407354-NIC-2 from Santa Cruz Biotechnology
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translin CRISPR Activation Plasmid (h) - sc-407354-ACT from Santa Cruz Biotechnology
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translin CRISPR Activation Plasmid (h2) - sc-407354-ACT-2 from Santa Cruz Biotechnology
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translin Lentiviral Activation Particles (h) - sc-407354-LAC from Santa Cruz Biotechnology
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translin Lentiviral Activation Particles (h2) - sc-407354-LAC-2 from Santa Cruz Biotechnology
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translin siRNA (h) - sc-38600 from Santa Cruz Biotechnology
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translin shRNA Plasmid (h) - sc-38600-SH from Santa Cruz Biotechnology
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translin shRNA (h) Lentiviral Particles - sc-38600-V from Santa Cruz Biotechnology
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Translin RNAi - H00007247-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN22097 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22097 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11517 from Sigma-Aldrich
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TSN siRNA (Human) - CRH4952 from Cohesion Biosciences
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TSN - MBS8217287 from MyBioSource
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shRNA set against Human TSN (NM_004622.2) - SHH436180 from Creative biogene
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shRNA set against Human TSN(NM_004622.2) - SHL099354 from Creative biogene
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Human TSN siRNA - orb265454 from Biorbyt
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TSN shRNA Plasmid (Human) - CHH4952 from Cohesion Biosciences
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TSN miRNA 3'UTR clone - MiUTR1H-10814 from Creative biogene
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