Gene Symbol | JAKMIP1 |
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Entrez Gene | 152789 |
Alt Symbol | Gababrbp, JAMIP1, MARLIN1 |
Species | Human |
Gene Type | protein-coding |
Description | janus kinase and microtubule interacting protein 1 |
Other Description | GABA-B receptor-binding protein|Jak and microtubule interacting protein 1|janus kinase and microtubule-interacting protein 1|marlin-1|multiple alpha-helices and RNA-linker protein 1|multiple coiled-coil GABABR1-binding protein |
Swissprots | A6H2J4 A6H2J5 Q8N7G3 Q96N16 A6H2J2 Q86Y69 B8ZZR7 D3DVT0 A8MTK6 A6H2J3 B4DHZ8 |
Accessions | EAW82401 EAW82402 Q96N16 AK056126 BAB71098 AK098536 BAC05325 AK124718 BAG54078 AK294356 BAG57621 AK295339 BAG58310 AK307983 AM412307 CAL80778 AM412308 CAL80779 AM412309 CAL80780 AM412310 CAL80781 AW157571 AY382340 AAR26235 BC026343 BC047075 AAH47075 BM714077 DA155551 JF432338 ADZ15555 XM_011513399 XP_011511701 XM_011513400 XP_011511702 XM_011513401 XP_011511703 NM_001099433 NP_001092903 NM_001306133 NP_001293062 NM_001306134 NP_001293063 NM_144720 NP_653321 |
Function | Associates with microtubules and may play a role in the microtubule-dependent transport of the GABA-B receptor. May play a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements. {ECO:0000269|PubMed:14718537, ECO:0000269|PubMed:15277531, ECO:0000269|PubMed:17532644}. |
Subcellular Location | Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Note=Colocalizes with the microtubule network. Localizes to the cell body and neurites of hippocampal neurons where it accumulates in granules. Localizes to the tail and to a lower extent to the head of sperm cells. |
Tissue Specificity | Predominantly expressed in neural tissues and lymphoid cells (at protein level). Isoform 2, isoform 3 and isoform 4 are specifically expressed in brain and retina. Isoform 1 and isoform 5 are also detected in liver, lung and skeletal muscle. Also detected in testis and to a lower extent spleen and intestine. {ECO:0000269|PubMed:15277531, ECO:0000269|PubMed:17761393}. |
Marlin-1 CRISPR/Cas9 KO Plasmid (h) - sc-414723 from Santa Cruz Biotechnology
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Marlin-1 HDR Plasmid (h) - sc-414723-HDR from Santa Cruz Biotechnology
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Marlin-1 Double Nickase Plasmid (h) - sc-414723-NIC from Santa Cruz Biotechnology
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Marlin-1 Double Nickase Plasmid (h2) - sc-414723-NIC-2 from Santa Cruz Biotechnology
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Marlin-1 CRISPR Activation Plasmid (h) - sc-414723-ACT from Santa Cruz Biotechnology
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Marlin-1 CRISPR Activation Plasmid (h2) - sc-414723-ACT-2 from Santa Cruz Biotechnology
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Marlin-1 Lentiviral Activation Particles (h) - sc-414723-LAC from Santa Cruz Biotechnology
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Marlin-1 Lentiviral Activation Particles (h2) - sc-414723-LAC-2 from Santa Cruz Biotechnology
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Marlin-1 siRNA (h) - sc-89100 from Santa Cruz Biotechnology
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Marlin-1 shRNA Plasmid (h) - sc-89100-SH from Santa Cruz Biotechnology
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Marlin-1 shRNA (h) Lentiviral Particles - sc-89100-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU041861 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10856 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10856 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01537 from Sigma-Aldrich
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JAKMIP1 siRNA (Human) - CRJ5748 from Cohesion Biosciences
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JAKMIP1, siRNA - MBS8215651 from MyBioSource
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shRNA set against Human JAKMIP1 (NM_144720.3) - SHH321947 from Creative biogene
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JAKMIP1 shRNA Plasmid (Human) - CHJ5748 from Cohesion Biosciences
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JAKMIP1 miRNA 3'UTR clone - MiUTR1H-05060 from Creative biogene
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