| Gene Symbol | IRF1 |
|---|---|
| Entrez Gene | 3659 |
| Alt Symbol | IRF-1, MAR |
| Species | Human |
| Gene Type | protein-coding |
| Description | interferon regulatory factor 1 |
| Other Description | interferon regulatory factor 1 isoform +I9|interferon regulatory factor 1 isoform d78|interferon regulatory factor 1 isoform delta4|interferon regulatory factor 1 isoform delta7 |
| Swissprots | Q96GG7 P10914 |
| Accessions | AAA36043 AAB93488 ABH05670 EAW62332 P10914 AA402319 AB103081 BAD89424 AB209624 BAD92861 AK298770 BAG60912 AK314025 BAG36735 BC009483 AAH09483 BT019755 AAV38560 BT019756 AAV38561 CR541713 CAG46514 DQ893269 ABM84195 DQ896599 ABM87598 KC209827 AGV15458 KC209828 AGV15459 KJ200632 AHW49376 KJ200633 AHW49377 KJ200634 AHW49378 KJ200635 LN607829 CEF49516 LN626686 CEH24701 X14454 CAA32624 XM_011543378 XP_011541680 XM_011543379 XP_011541681 XR_427711 NM_002198 NP_002189 |
| Function | Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. These include the regulation of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon- stimulated response element (ISRE) in their promoters. Its target genes for transcriptional activation activity include: genes involved in anti-viral response, such as IFN-alpha/beta, DDX58/RIG-I, TNFSF10/TRAIL, OAS1/2, PIAS1/GBP, EIF2AK2/PKR and RSAD2/viperin; antibacterial response, such as NOS2/INOS; anti- proliferativ |
| Subcellular Location | Nucleus. Cytoplasm. Note=MYD88-associated IRF1 migrates into the nucleus more efficiently than non-MYD88- associated IRF1. |
| Top Pathways | Hepatitis C, Pertussis, Prolactin signaling pathway |