IRF1

Gene Symbol IRF1
Entrez Gene 3659
Alt Symbol IRF-1, MAR
Species Human
Gene Type protein-coding
Description interferon regulatory factor 1
Other Description interferon regulatory factor 1 isoform +I9|interferon regulatory factor 1 isoform d78|interferon regulatory factor 1 isoform delta4|interferon regulatory factor 1 isoform delta7
Swissprots Q96GG7 P10914
Accessions AAA36043 AAB93488 ABH05670 EAW62332 P10914 AA402319 AB103081 BAD89424 AB209624 BAD92861 AK298770 BAG60912 AK314025 BAG36735 BC009483 AAH09483 BT019755 AAV38560 BT019756 AAV38561 CR541713 CAG46514 DQ893269 ABM84195 DQ896599 ABM87598 KC209827 AGV15458 KC209828 AGV15459 KJ200632 AHW49376 KJ200633 AHW49377 KJ200634 AHW49378 KJ200635 LN607829 CEF49516 LN626686 CEH24701 X14454 CAA32624 XM_011543378 XP_011541680 XM_011543379 XP_011541681 XR_427711 NM_002198 NP_002189
Function Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. These include the regulation of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon- stimulated response element (ISRE) in their promoters. Its target genes for transcriptional activation activity include: genes involved in anti-viral response, such as IFN-alpha/beta, DDX58/RIG-I, TNFSF10/TRAIL, OAS1/2, PIAS1/GBP, EIF2AK2/PKR and RSAD2/viperin; antibacterial response, such as NOS2/INOS; anti- proliferativ
Subcellular Location Nucleus. Cytoplasm. Note=MYD88-associated IRF1 migrates into the nucleus more efficiently than non-MYD88- associated IRF1.
Top Pathways Hepatitis C, Pertussis, Prolactin signaling pathway

IRF-1 (D5E4) XP ® Rabbit mAb (PE Conjugate) - 12732 from Cell Signaling Technology

Prices $329.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone D5E4
Flow cytometric analysis of HeLa cells, untreated (blue) or treated with Human Interferon-γ (hIFN-γ) #8901 (green), using IRF-1 (D5E4) XP ® Rabbit mAb (PE Conjugate).

IRF-1 (D5E4) XP ® Rabbit mAb (Alexa Fluor ® 647 Conjugate) - 14105 from Cell Signaling Technology

Prices $329.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone D5E4
Flow cytometric analysis of HeLa cells, untreated (blue) or treated with Human Interferon-γ (hIFN-γ) #8901 (green), using IRF-1 (D5E4) XP ® Rabbit mAb (Alexa Fluor ® 647 Conjugate).

IRF-1 (D5E4) XP ® Rabbit mAb (Alexa Fluor ® 488 Conjugate) - 14028 from Cell Signaling Technology

Prices $329.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone D5E4
Flow cytometric analysis of HeLa cells, untreated (blue) or treated with Human Interferon-γ (hIFN-γ) #8901 (green), using IRF-1 (D5E4) XP ® Rabbit mAb (Alexa Fluor ® 488 Conjugate).

IRF-1 (D5E4) XP ® Rabbit mAb - 8478 from Cell Signaling Technology

Prices $109.00, $277.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D5E4
Western blot analysis of HeLa cells, untreated or treated with Human Interferon-γ (hIFN-γ) #8901 (100 ng/ml, 4 hr), using IRF-1 (D5E4) XP ® Rabbit mAb.

IRF-1 Antibody - 4966 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

IRF-1 (C-20) - sc-497 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IRF-1 (C-20): sc-497. Western blot analysis of IRF-1 expression in Jurkat whole cell lysate.

IRF-1 (B-1) - sc-137061 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IRF-1 (B-1): sc-137061. Western blot analysis of IRF-1 expression in Jurkat nuclear extract.

IRF-1 (H-205) - sc-13041 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IRF-1 (H-205): sc-13041. Western blot analysis of IRF-1 expression in non-transfected 293T: sc-117752 (A), human IRF-1 transfected 293T: sc-159114 (B) and Jurkat (C) whole cell lysates.

IRF-1 (H-8) - sc-74530 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IRF-1 (H-8): sc-74530. Western blot analysis of IRF-1 expression in Jurkat nuclear extract.

IRF-1 (M-20) - sc-640 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IRF-1 (M-20): sc-640. Western blot analysis of IRF-1 expression in whole cell lysates prepared from IFN-γ-induced (A) and control (B) RAW 264.7 cells.

IRF-1 (20) - sc-135952 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
IRF-1 (20): sc-135952. Western blot analysis of IRF-1 expression in MOLT-3 whole cell lysate.

Anti-IRF1 antibody - ab191032 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded human intestinal cancer tissue labeling IRF1 with ab191032 at 1 μg/ml.

Anti-IRF1 antibody - ab55330 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-IRF1 antibody - ab52709 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Polyclonal

Anti-IRF1 antibody [EPR18301] - ab186384 from Abcam

Prices $99.00
Sizes 10 µl
Host Rabbit
Clonality Monoclonal
Clone EPR18301
Immunofluorescent analysis of 4% paraformaldehyde-fixed, 0.1% Triton X-100 permeabilized MOLT-4 (Human lymphoblastic leukemia) cells labeling IRF1 with ab186384 at 1/500 dilution, followed by Goat anti-rabbit IgG (Alexa Fluor® 488) (ab150077) secondary antibody at 1/500 dilution (green).Confocal image showing nuclear and cytoplasmic staining on MOLT-4 cells.The nuclear counterstain is DAPI (blue).Tubulin is detected with ab7291 (anti-Tubulin mouse mAb) at 1/1000 dilution and ab150120 (AlexaFluor®594 Goat anti-Mouse secondary) at 1/500 dilution (red).The negative controls are as follows:--ve control 1 - ab186384 at 1/500 dilution followed by ab150120 (AlexaFluor®594 Goat anti-Mouse secondary) at 1/500 dilution.-ve control 2. - ab7291 (anti-Tubulin mouse mAb) at 1/1000 dilution followed by ab150077 (Alexa Fluor®488 Goat Anti-Rabbit IgG H&L) at 1/500 dilution.

Anti-IRF1 / MAR Antibody (aa169-183) - LS-C313338 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IRF1 / IRF-1 /MAR antibody. IHC(P): Human Intestinal Cancer Tissue.

Anti-IRF1 / MAR Antibody (aa266-293, AP) - LS-C260353 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IRF1 / MAR Antibody (aa256-305) - LS-C146383 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
IRF1 antibody LS-C146383 Western blot of HeLa Cell lysate. Antibody concentration 1 ug/ml.

Anti-IRF1 / MAR Antibody (aa110-159) - LS-C79958 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
HepG2 cell lysate. Antibody concentration: 1.2 ug/ml. Gel concentration: 12%.

Anti-IRF1 / MAR Antibody (aa266-293, Biotin) - LS-C260354 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IRF1 / MAR Antibody (aa251-300) - LS-C116008 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
IRF1 antibody LS-C116008 Western blot of Mouse Muscle lysate.

Anti-IRF1 / MAR Antibody (aa201-250) - LS-C116009 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
IRF1 antibody LS-C116009 Western blot of Mouse Uterus lysate.

Anti-IRF1 / MAR Antibody (aa266-293, APC) - LS-C260355 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IRF1 / MAR Antibody (aa266-293, PE) - LS-C260358 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IRF1 / MAR Antibody (aa266-293, FITC) - LS-C260356 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Search more