IRF1

Gene Symbol	IRF1
Entrez Gene	3659
Alt Symbol	IRF-1, MAR
Species	Human
Gene Type	protein-coding
Description	interferon regulatory factor 1
Other Description	interferon regulatory factor 1 isoform +I9|interferon regulatory factor 1 isoform d78|interferon regulatory factor 1 isoform delta4|interferon regulatory factor 1 isoform delta7
Swissprots	Q96GG7 P10914
Accessions	AAA36043 AAB93488 ABH05670 EAW62332 P10914 AA402319 AB103081 BAD89424 AB209624 BAD92861 AK298770 BAG60912 AK314025 BAG36735 BC009483 AAH09483 BT019755 AAV38560 BT019756 AAV38561 CR541713 CAG46514 DQ893269 ABM84195 DQ896599 ABM87598 KC209827 AGV15458 KC209828 AGV15459 KJ200632 AHW49376 KJ200633 AHW49377 KJ200634 AHW49378 KJ200635 LN607829 CEF49516 LN626686 CEH24701 X14454 CAA32624 XM_011543378 XP_011541680 XM_011543379 XP_011541681 XR_427711 NM_002198 NP_002189
Function	Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. These include the regulation of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon- stimulated response element (ISRE) in their promoters. Its target genes for transcriptional activation activity include: genes involved in anti-viral response, such as IFN-alpha/beta, DDX58/RIG-I, TNFSF10/TRAIL, OAS1/2, PIAS1/GBP, EIF2AK2/PKR and RSAD2/viperin; antibacterial response, such as NOS2/INOS; anti- proliferativ
Subcellular Location	Nucleus. Cytoplasm. Note=MYD88-associated IRF1 migrates into the nucleus more efficiently than non-MYD88- associated IRF1.
Top Pathways	Hepatitis C, Pertussis, Prolactin signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human IRF1 full length protein - ab132327 from Abcam Category Protein Source Wheat germ Species Human

Human IRF1 peptide - ab27763 from Abcam Category Peptide

Human IRF1 protein fragment - ab73452 from Abcam Category Protein Source E. coli Species Human

IRF1 / MAR Antibody Blocking Peptide - LS-E759 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IRF1 / MAR Antibody Blocking Peptide - LS-E1270 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IRF1 / MAR Antibody Blocking Peptide - LS-E10925 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IRF1 / MAR Antibody Blocking Peptide - LS-E13232 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IRF1 / MAR Antibody Blocking Peptide - LS-E13233 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IRF1 / MAR Antibody Blocking Peptide - LS-E13682 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IRF1 Recombinant Protein - H00003659-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

IRF1 Partial Recombinant Protein - H00003659-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human IRF1 Protein - NBC1-18471 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Species Human

IRF1-Antibody-C-term-Blocking-peptide - BP11115b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

IRF1-Antibody-Center-Blocking-peptide - BP11860c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

IRF 1 Protein (OPPA00708) - OPPA00708 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human IRF 1 protein - orb80393 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

IRF-1 peptide - orb72892 from Biorbyt Category Peptide Prices $238.00 Sizes 500 µg

IRF1 protein (His tag) - 80R-1026 from Fitzgerald Category Protein Prices $255.00 Sizes 100 µg Source E.coli

Human IRF1 Protein - abx067373 from Abbexa Category Protein Source E.coli Species Human

IRF1 Blocking Peptide - abx161139 from Abbexa Category Peptide Species Human, Mouse, Rat, Dog, Monkey, Pig

IRF1 (1-114, His-tag) - AR09055PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

IRF1 (1-114, His-tag) - AR09055PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

IRF1 - H00003659-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

IRF1 - H00003659-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

IRF1 - H00003659-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

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