| Gene Symbol |
SCN3B
|
| Entrez Gene |
55800
|
| Alt Symbol |
ATFB16, BRGDA7, HSA243396, SCNB3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sodium channel, voltage gated, type III beta subunit
|
| Other Description |
sodium channel subunit beta-3|sodium channel, voltage-gated, type III, beta subunit|voltage-gated sodium channel beta-3 subunit
|
| Swissprots |
A5H1I5 Q9ULR2 Q17RL3 Q9NY72
|
| Accessions |
ABQ01237 EAW67550 EAW67551 EAW67552 Q9NY72 AB032984 BAA86472 AJ243396 CAB76825 AK055033 AK314513 BAG37113 AL136589 CAB66524 AM393297 CAL38175 BC045704 BC117282 AAI17283 BC126265 AAI26266 BP202832 BX106794 DA327760 DA806480 HQ258123 ADR82877 XM_011542897 XP_011541199 XR_947858 NM_001040151 NP_001035241 NM_018400 NP_060870
|
| Function |
Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Expressed in the atrium. {ECO:0000269|PubMed:21051419}.
|
![Western Blot: SCN3B Overexpression Lysate (Adult Normal) [NBL1-15743] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SCN3B.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/26247_SCN3B%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-15743-img0002.jpg)
![Western Blot: SCN3B Overexpression Lysate (Adult Normal) [NBP2-08505] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SCN3B.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/14698_SCN3B%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-08505-img0001.jpg)
![Western Blot: SCN3B Overexpression Lysate (Adult Normal) [NBP2-09212] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SCN3B.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10380_SCN3B%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-09212-img0001.jpg)