Gene Symbol | SCN3B |
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Entrez Gene | 55800 |
Alt Symbol | ATFB16, BRGDA7, HSA243396, SCNB3 |
Species | Human |
Gene Type | protein-coding |
Description | sodium channel, voltage gated, type III beta subunit |
Other Description | sodium channel subunit beta-3|sodium channel, voltage-gated, type III, beta subunit|voltage-gated sodium channel beta-3 subunit |
Swissprots | A5H1I5 Q9ULR2 Q17RL3 Q9NY72 |
Accessions | ABQ01237 EAW67550 EAW67551 EAW67552 Q9NY72 AB032984 BAA86472 AJ243396 CAB76825 AK055033 AK314513 BAG37113 AL136589 CAB66524 AM393297 CAL38175 BC045704 BC117282 AAI17283 BC126265 AAI26266 BP202832 BX106794 DA327760 DA806480 HQ258123 ADR82877 XM_011542897 XP_011541199 XR_947858 NM_001040151 NP_001035241 NM_018400 NP_060870 |
Function | Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity). {ECO:0000250}. |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Tissue Specificity | Expressed in the atrium. {ECO:0000269|PubMed:21051419}. |
Na + CP type IIIβ CRISPR/Cas9 KO Plasmid (h) - sc-408078 from Santa Cruz Biotechnology
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Na + CP type IIIβ HDR Plasmid (h) - sc-408078-HDR from Santa Cruz Biotechnology
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Na + CP type IIIβ Double Nickase Plasmid (h) - sc-408078-NIC from Santa Cruz Biotechnology
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Na + CP type IIIβ Double Nickase Plasmid (h2) - sc-408078-NIC-2 from Santa Cruz Biotechnology
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Na + CP type IIIβ CRISPR Activation Plasmid (h) - sc-408078-ACT from Santa Cruz Biotechnology
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Na + CP type IIIβ CRISPR Activation Plasmid (h2) - sc-408078-ACT-2 from Santa Cruz Biotechnology
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Na + CP type IIIβ Lentiviral Activation Particles (h) - sc-408078-LAC from Santa Cruz Biotechnology
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Na + CP type IIIβ Lentiviral Activation Particles (h2) - sc-408078-LAC-2 from Santa Cruz Biotechnology
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Na + CP type IIIβ siRNA (h) - sc-61136 from Santa Cruz Biotechnology
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Na+ CP type IIIβ shRNA Plasmid (h) - sc-61136-SH from Santa Cruz Biotechnology
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Na+ CP type IIIβ shRNA (h) Lentiviral Particles - sc-61136-V from Santa Cruz Biotechnology
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SCN3B RNAi - H00055800-R01 from Novus Biologicals
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MISSION® esiRNA - EHU045251 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18955 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18955 from Sigma-Aldrich
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SCN3B siRNA (Human) - CRJ0932 from Cohesion Biosciences
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SCN3B - MBS8222543 from MyBioSource
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shRNA set against Human SCN3B (NM_018400.3) - SHH402844 from Creative biogene
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shRNA set against Human SCN3B(NM_001040151.1) - SHR208770 from Creative biogene
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Human SCN3B siRNA - orb271433 from Biorbyt
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SCN3B shRNA Plasmid (Human) - CHJ0932 from Cohesion Biosciences
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SCN3B miRNA 3'UTR clone - MiUTR1H-09187 from Creative biogene
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SCN3B miRNA 3'UTR clone - MiUTR4H-TG07846 from Creative biogene
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