| Gene Symbol |
E2F3
|
| Entrez Gene |
1871
|
| Alt Symbol |
E2F-3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
E2F transcription factor 3
|
| Other Description |
transcription factor E2F3
|
| Swissprots |
Q68DT0 O00716 Q9BZ44 Q15000
|
| Accessions |
AAN17846 EAW55421 EAW55422 EAW55423 O00716 BC016847 AAH16847 BC099908 AAH99908 BC114554 AAI14555 BC156367 AAI56368 BC172526 AAI72526 BU633769 CR749285 CAH18140 D38550 BAA07553 HG499031 W38841 Y10479 CAA71504 XM_005248865 XP_005248922 XM_005248866 XP_005248923 XM_011514324 XP_011512626 XM_011514325 XP_011512627 XM_011514326 XP_011512628 XM_011514327 XP_011512629 XM_011514328 XP_011512630 XM_011514329 XP_011512631 XR_926084 NM_001243076 NP_001230005 NM_001949 NP_001940
|
| Function |
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters (By similarity). {ECO:0000250|UniProtKB:O35261}.
|
| Subcellular Location |
Nucleus.
|
| Top Pathways |
MicroRNAs in cancer, Cell cycle, HTLV-I infection, Prostate cancer, Glioma
|