Gene Symbol | E2F3 |
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Entrez Gene | 1871 |
Alt Symbol | E2F-3 |
Species | Human |
Gene Type | protein-coding |
Description | E2F transcription factor 3 |
Other Description | transcription factor E2F3 |
Swissprots | Q68DT0 O00716 Q9BZ44 Q15000 |
Accessions | AAN17846 EAW55421 EAW55422 EAW55423 O00716 BC016847 AAH16847 BC099908 AAH99908 BC114554 AAI14555 BC156367 AAI56368 BC172526 AAI72526 BU633769 CR749285 CAH18140 D38550 BAA07553 HG499031 W38841 Y10479 CAA71504 XM_005248865 XP_005248922 XM_005248866 XP_005248923 XM_011514324 XP_011512626 XM_011514325 XP_011512627 XM_011514326 XP_011512628 XM_011514327 XP_011512629 XM_011514328 XP_011512630 XM_011514329 XP_011512631 XR_926084 NM_001243076 NP_001230005 NM_001949 NP_001940 |
Function | Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters (By similarity). {ECO:0000250|UniProtKB:O35261}. |
Subcellular Location | Nucleus. |
Top Pathways | MicroRNAs in cancer, Cell cycle, HTLV-I infection, Prostate cancer, Glioma |
E2F-3 CRISPR/Cas9 KO Plasmid (h) - sc-400934 from Santa Cruz Biotechnology
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E2F-3 HDR Plasmid (h) - sc-400934-HDR from Santa Cruz Biotechnology
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E2F-3 Double Nickase Plasmid (h) - sc-400934-NIC from Santa Cruz Biotechnology
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E2F-3 Double Nickase Plasmid (h2) - sc-400934-NIC-2 from Santa Cruz Biotechnology
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E2F-3 CRISPR Activation Plasmid (h) - sc-400934-ACT from Santa Cruz Biotechnology
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E2F-3 CRISPR Activation Plasmid (h2) - sc-400934-ACT-2 from Santa Cruz Biotechnology
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E2F-3 Lentiviral Activation Particles (h) - sc-400934-LAC from Santa Cruz Biotechnology
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E2F-3 Lentiviral Activation Particles (h2) - sc-400934-LAC-2 from Santa Cruz Biotechnology
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E2F-3 siRNA (h) - sc-37817 from Santa Cruz Biotechnology
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E2F-3 shRNA Plasmid (h) - sc-37817-SH from Santa Cruz Biotechnology
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E2F-3 shRNA (h) Lentiviral Particles - sc-37817-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU057281 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7606 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7606 from Sigma-Aldrich
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E2F3 siRNA (Human) - CRH1308 from Cohesion Biosciences
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E2F3 RNAi - H00001871-R01 from Novus Biologicals
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E2F3 - MBS828008 from MyBioSource
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Human E2F3 siRNA - orb261810 from Biorbyt
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E2F3 shRNA Plasmid (Human) - CHH1308 from Cohesion Biosciences
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E2F3 miRNA 3'UTR clone - MiUTR3H-03369 from Creative biogene
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