| Gene Symbol |
Grin2b
|
| Entrez Gene |
24410
|
| Alt Symbol |
GluN2B
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
|
| Other Description |
N-methyl D-aspartate receptor subtype 2B|NMDAR2B|NR2B|glutamate [NMDA] receptor subunit epsilon-2|glutamate receptor ionotropic, NMDA 2B|glutamate receptor, ionotropic, NMDA2B
|
| Swissprots |
Q00960 Q62684
|
| Accessions |
EDM01617 EDM01618 Q00960 M91562 AAA41714 U11419 AAA50554 NM_012574 NP_036706
|
| Function |
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
|
| Top Pathways |
Rap1 signaling pathway, Circadian entrainment, Alcoholism, Cocaine addiction, cAMP signaling pathway
|