| Gene Symbol |
ZFYVE26
|
| Entrez Gene |
23503
|
| Alt Symbol |
FYVE-CENT, SPG15
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
zinc finger, FYVE domain containing 26
|
| Other Description |
FYVE domain-containing centrosomal protein|spastizin|zinc finger FYVE domain-containing protein 26
|
| Swissprots |
O15035 Q6ZR50 Q68DT9 B1B5Y3 B4E2U3 Q7Z3I1 Q68DK2 Q6AW90 Q8N4W7 Q7Z3A4
|
| Accessions |
EAW80952 EAW80953 EAW80954 EAW80955 EAW80956 Q68DK2 AB002319 BAA20779 AB425197 BAG11658 AK024743 AK304428 BAG65255 AK308233 BC008927 AAH08927 BC013909 BC033235 AAH33235 BC144594 BC172413 AAI72413 BX537886 CAD97882 BX538025 CAD97971 BX648036 BX648683 CAH10379 CR749276 CAH18131 CR749365 CAH18218 XM_006720093 XP_006720156 XM_011536606 XP_011534908 XM_011536607 XP_011534909 XM_011536608 XP_011534910 XM_011536609 XP_011534911 NM_015346 NP_056161
|
| Function |
Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair. {ECO:0000269|PubMed:20208530}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20208530}. Midbody {ECO:0000269|PubMed:20208530}. Note=Localizes to the centrosome during all stages of the cell cycle. Recruited to the midbody during cytokinesis by KIF13A.
|
| Tissue Specificity |
Strongest expression in the adrenal gland, bone marrow, adult brain, fetal brain, lung, placenta, prostate, skeletal muscle, testis, thymus, and retina. Intermediate levels are detected in other structures, including the spinal cord. {ECO:0000269|PubMed:18394578}.
|