B4GAT1

Gene Symbol B4GAT1
Entrez Gene 11041
Alt Symbol B3GN-T1, B3GNT1, B3GNT6, BETA3GNTI, MDDGA13, iGAT, iGNT
Species Human
Gene Type protein-coding
Description beta-1,4-glucuronyltransferase 1
Other Description N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase|UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1|UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6|beta-1,3-N-acetylglucosaminyltransferase bGnT-6|i-beta-1,3-N-acetylglucosaminyltransferase|poly-N-acetyllactosamine extension enzyme
Swissprots O43505 Q4TTN0
Accessions AAY46155 EAW74517 EAW74518 O43505 AF029893 AAC39538 AK075354 BAG52119 AK098389 AK098779 AK225182 AK293715 BAG57146 AK294604 BAG57791 BC021965 AAH21965 DA169103 DQ892706 ABM83632 DQ895957 ABM86883 NM_006876 NP_006867
Function Beta-1,4-glucuronyltransferase involved in O- mannosylation of alpha-dystroglycan (DAG1). Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor to produce the glucuronyl-beta-1,4-xylose-beta disaccharide primer, which is further elongated by LARGE, during synthesis of phosphorylated O- mannosyl glycan (PubMed:25279699, PubMed:25279697). Phosphorylated O-mannosyl glycan is a carbohydrate is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:25279699, PubMed:25279697). Required for axon guidance; via its function in O-mannosylation of alpha- dystroglycan (DAG1) (By similarity). {ECO:0000250|UniProtKB:Q8BWP8, ECO:0000269|PubMed:19587235, ECO:0000269|PubMed:23359570, ECO:0000269|PubMed:25279697, ECO:0000269|PubMed:25279699}.
Subcellular Location Golgi apparatus membrane {ECO:0000269|PubMed:19587235, ECO:0000269|PubMed:23359570, ECO:0000269|PubMed:25279699}; Single-pass type II membrane protein {ECO:0000269|PubMed:23359570}. Note=Localizes near the trans-Golgi apparatus. {ECO:0000269|PubMed:25279699}.
Tissue Specificity In the adult, highly expressed in heart, brain, skeletal muscle and kidney and to a lesser extent in placenta, pancreas, spleen, prostate, testis, ovary, small intestine and colon. Very weak expression in lung, liver, thymus and peripheral blood leukocytes. In fetal highly expressed in brain and kidney and to a lesser extent in lung and liver. {ECO:0000269|PubMed:9405606}.
Top Pathways Glycosaminoglycan biosynthesis - keratan sulfate, Glycosphingolipid biosynthesis - lacto and neolacto series

Anti-B3GNT antibody - ab118083 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Detection limit for ab118083 is 3 ng/ml as a capture antibody. This antibody has only been tested against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

Anti-B3GNT antibody - ab167446 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-B3GNT antibody (ab167446) at 1 µg/ml + Mouse testis lysate at 10 µg

Anti-B4GAT1 / B3GNT1 Antibody (aa43-415, clone 12K14) - LS-C182765 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 12K14

Anti-B4GAT1 / B3GNT1 Antibody (aa366-394, AP) - LS-C252197 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-B4GAT1 / B3GNT1 Antibody (aa366-394, APC) - LS-C252199 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-B4GAT1 / B3GNT1 Antibody (aa366-394, Biotin) - LS-C252200 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-B4GAT1 / B3GNT1 Antibody (aa366-394, FITC) - LS-C252201 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-B4GAT1 / B3GNT1 Antibody (aa366-394, Azide-free, HRP) - LS-C252202 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-B4GAT1 / B3GNT1 Antibody (aa316-416) - LS-C306478 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-B4GAT1 / B3GNT1 Antibody (aa366-394, PE) - LS-C252203 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-B4GAT1 / B3GNT1 Antibody (aa365-394) - LS-C319738 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-B4GAT1 / B3GNT1 Antibody (Internal) - LS-C345872 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of B3gnt1 Antibody - middle region in Mouse Testis cells lysate.

Anti-B4GAT1 / B3GNT1 Antibody (aa366-394) - LS-C156710 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
B3GNT1 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-B4GAT1 / B3GNT1 Antibody (aa146-173) - LS-C156713 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
B3GNT6 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human colon carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.

Beta-1,3-N-Acetylglucosaminyltransferase 1/B3GNT1 Antibody - AF6664 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Sheep
Clonality Polyclonal
Western blot shows lysates of human muscle tissue and mouse muscle tissue. PVDF Membrane was probed with 1 µg/mL of Human beta -1,3-N-acetylglucosaminyltransferase 1/B3GNT1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6664) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016). A specific band was detected for beta -1,3-N-acetylglucosaminyltransferase 1/B3GNT1 at approximately 50 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8.

Beta-1,3-N-Acetylglucosaminyltransferase 1/B3GNT1 Antibody (724057) - MAB6664 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 724057

Beta-1,3-N-Acetylglucosaminyltransferase 1/B3GNT1 Antibody - NBP1-88952 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: B3GNT1 Antibody [NBP1-88952] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Negative control (vector only transfected HEK293T lysate). Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).

Anti-B3GNT1 antibody produced in rabbit - HPA015484 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-AP001107.5: <B>Cat. No. HPA015484</B>: Immunohistochemical staining of human hippocampus shows strong cytoplasmic positivity in neuronal cells.

ANTI-B3GNT1(C-TERMINAL) antibody produced in rabbit - SAB1307038 from Sigma-Aldrich

Prices $326.00
Sizes 40 tst
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-B3GNT1 (C-term): <B>Cat. No. SAB1307038</B>: B3GNT1 Antibody (C-term) western blot analysis in MDA-MB435 cell line lysates (35 μg/lane)

Monoclonal Anti-B3GNT6, (C-terminal) antibody produced in mouse - SAB1403100 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2H6
<B>ELISA</B><BR/>Monoclonal Anti-B3GNT6: <B>Cat. No. SAB1403100</B>: Detection limit for recombinant GST tagged B3GNT1 is 3 ng/mL.

B3GNT1-Antibody-C-term - AP13200b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
B3GNT1 Antibody (C-term) (Cat. #AP13200b) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the B3GNT1 antibody detected the B3GNT1 protein (arrow).

B3GNT1 Antibody - C-terminal region (OAAB09505) - OAAB09505 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
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