B4GAT1

Gene Symbol	B4GAT1
Entrez Gene	11041
Alt Symbol	B3GN-T1, B3GNT1, B3GNT6, BETA3GNTI, MDDGA13, iGAT, iGNT
Species	Human
Gene Type	protein-coding
Description	beta-1,4-glucuronyltransferase 1
Other Description	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase|UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1|UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6|beta-1,3-N-acetylglucosaminyltransferase bGnT-6|i-beta-1,3-N-acetylglucosaminyltransferase|poly-N-acetyllactosamine extension enzyme
Swissprots	O43505 Q4TTN0
Accessions	AAY46155 EAW74517 EAW74518 O43505 AF029893 AAC39538 AK075354 BAG52119 AK098389 AK098779 AK225182 AK293715 BAG57146 AK294604 BAG57791 BC021965 AAH21965 DA169103 DQ892706 ABM83632 DQ895957 ABM86883 NM_006876 NP_006867
Function	Beta-1,4-glucuronyltransferase involved in O- mannosylation of alpha-dystroglycan (DAG1). Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor to produce the glucuronyl-beta-1,4-xylose-beta disaccharide primer, which is further elongated by LARGE, during synthesis of phosphorylated O- mannosyl glycan (PubMed:25279699, PubMed:25279697). Phosphorylated O-mannosyl glycan is a carbohydrate is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:25279699, PubMed:25279697). Required for axon guidance; via its function in O-mannosylation of alpha- dystroglycan (DAG1) (By similarity). {ECO:0000250|UniProtKB:Q8BWP8, ECO:0000269|PubMed:19587235, ECO:0000269|PubMed:23359570, ECO:0000269|PubMed:25279697, ECO:0000269|PubMed:25279699}.
Subcellular Location	Golgi apparatus membrane {ECO:0000269|PubMed:19587235, ECO:0000269|PubMed:23359570, ECO:0000269|PubMed:25279699}; Single-pass type II membrane protein {ECO:0000269|PubMed:23359570}. Note=Localizes near the trans-Golgi apparatus. {ECO:0000269|PubMed:25279699}.
Tissue Specificity	In the adult, highly expressed in heart, brain, skeletal muscle and kidney and to a lesser extent in placenta, pancreas, spleen, prostate, testis, ovary, small intestine and colon. Very weak expression in lung, liver, thymus and peripheral blood leukocytes. In fetal highly expressed in brain and kidney and to a lesser extent in lung and liver. {ECO:0000269|PubMed:9405606}.
Top Pathways	Glycosaminoglycan biosynthesis - keratan sulfate, Glycosphingolipid biosynthesis - lacto and neolacto series

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human B3GNT full length protein - ab161261 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human B3GNT protein fragment - ab161262 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

B4GAT1 / B3GNT1 Antibody Blocking Peptide - LS-E2266 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

B4GAT1 / B3GNT1 Antibody Blocking Peptide - LS-E10373 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Beta-1,3-N-Acetylglucosaminyltransferase 1/B3GNT1 Partial Recombinant Protein - H00011041-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Beta-1,3-N-Acetylglucosaminyltransferase 1/B3GNT1 Recombinant Protein - H00011041-P01 from Novus Biologicals Category Protein Species Human

Recombinant Human Beta-1,3-N-Acetylglucosaminyltransferase 1/B3GNT1 Protein - H00192134-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

B3GNT1-Antibody-C-term-Blocking-Peptide - BP13200b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human B3GNT1 protein - orb180348 from Biorbyt Category Protein Prices $323.00, $485.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Source HEK293 Species Human

Human B3GNT1 (His Tag) protein - orb232340 from Biorbyt Category Protein Prices $400.00, $816.00 Sizes 20 μg, 100 μg Species Human

B3GNT1 / B3GNT6 - H00011041-P01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

B3GNT1 / B3GNT6 - H00011041-P01-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Species Human

B3GNT1 / B3GNT6 - H00011041-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

B3GNT1 / B3GNT6 - H00011041-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

B3GNT1 fusion protein - Ag8660 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

B3GNT1 fusion protein - Ag8644 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human B3GNT1, GST-tagged - B3GNT1-10102H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human B3GNT1, His-tagged - B3GNT1-41H from Creative Biomart Category Protein Source HEK293 Species Human

Recombinant Human N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase - CSB-YP002499HU CSB-EP002499HU CSB-BP002499HU CSB-MP002499HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

B3GNT1 / B3GNT6 - TP300256 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Recombinant Human B3GNT1 Protein, His-tagged - B3GNT1-634H from Creative Biomart Category Protein Source HEK293 Species Human

Beta-1,3-N-Acetylglucosaminyltransferase 1/B3GNT1 Recombinant Protein Antigen - NBP1-88952PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

B3GNT1 Peptide, Human - M34GP01266H from Creative Peptides Category Peptide Source Synthetic. Species Human

Human B3GNT1 Protein (His Tag) - 14779-H07H from ABclonal Category Protein Prices $178.00, $448.00 Sizes 20 µg, 100 µg Source Human Cells Species Human

B3GNT1 Recombinant Protein - 91-704 from ProSci Category Protein Prices $425.00 Sizes 50 µg Source Human Cells Species Human

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