| Gene Symbol |
CENPK
|
| Entrez Gene |
64105
|
| Alt Symbol |
AF5alpha, CENP-K, FKSG14, P33, Solt
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
centromere protein K
|
| Other Description |
SoxLZ/Sox6-binding protein Solt|interphase centromere complex protein 37|leucine zipper protein FKSG14|protein AF-5alpha
|
| Swissprots |
Q9BS16 Q9H4L0
|
| Accessions |
EAW51353 EAW51354 Q9BS16 AF315941 AAL26880 AY009151 AAG31004 BC005400 AAH05400 BC008504 AAH08504 BG502832 DQ892541 ABM83467 DQ895752 ABM86678 XM_011543534 XP_011541836 XM_011543535 XP_011541837 XM_011543536 XP_011541838 XM_011543537 XP_011541839 XM_011543538 XP_011541840 XM_011543539 XP_011541841 XM_011543540 XP_011541842 XM_011543541 XP_011541843 XM_011543542 XP_011541844 XM_011543543 XP_011541845 XR_948282 NM_001267038 NP_001253967 NM_022145 NP_071428
|
| Function |
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Acts in coordination with CASC5/KNL1 to recruit the NDC80 complex to the outer kinetochore. {ECO:0000269|PubMed:16622420, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:18045986}.
|
| Subcellular Location |
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
|
| Tissue Specificity |
Detected in several fetal organs with highest levels in fetal liver. In adults, it is weakly expressed in lung and placenta. {ECO:0000269|PubMed:8950979}.
|