MUSK

Gene Symbol	MUSK
Entrez Gene	4593
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	muscle, skeletal, receptor tyrosine kinase
Other Description	muscle, skeletal receptor tyrosine-protein kinase|muscle-specific kinase receptor|muscle-specific tyrosine-protein kinase receptor
Swissprots	O15146 Q5VZW7 Q32MJ8 Q32MJ9 Q5VZW8
Accessions	EAW59065 EAW59066 EAW59067 O15146 AA448972 AF006464 AAB63044 BC109098 AAI09099 BC109099 AAI09100 BG825304 EU832778 ACE87789 EU832779 ACE87790 GQ129313 ACT64447 Z25436 CAA80923 XM_005251994 XP_005252051 XM_005251995 XP_005252052 XM_005251996 XP_005252053 XM_011518707 XP_011517009 XM_011518708 XP_011517010 NM_001166280 NP_001159752 NM_001166281 NP_001159753 NM_005592 NP_005583
Function	Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylati
Subcellular Location	Cell junction, synapse, postsynaptic cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Localizes to the postsynaptic cell membrane of the neuromuscular junction. {ECO:0000305}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MUSK ELISA Kit (Sandwich ELISA) - LS-F6766 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.055 ng/ml Range 0.156-10 ng/ml

Mouse MUSK ELISA Kit (Sandwich ELISA) - LS-F7368 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

Phosphotyrosine MUSK / Muscle, Skeletal Receptor Tyrosine-protein Kinase ELISA Kit - RAB0981 from Sigma-Aldrich Category ELISA Kit Prices $637.00 Sizes 1 kt

Anti Muscle, Skeletal, Receptor Tyrosine Kinase Antibody (Anti MUSK) BioAssay™ ELISA Kit(Human) - 179994 from USBiological Life Science Category ELISA Kit Sensitivity 0.1ng/mL Range 2.5-50ng/mL

Human MuSK ELISA Kit - abx054135 from Abbexa Category ELISA Kit Sensitivity 12 pg/ml Range 36 pg/ml - 2000 pg/ml

Human MUSK ELISA Kit - abx152406 from Abbexa Category ELISA Kit Sensitivity 0.054 ng/ml Range 0.156 ng/ml - 10 ng/ml

Anti-Muscle, Skeletal, receptor tyrosine kinase Antibody, Human, ELISA Kit - E01A0452 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 0.1ng/mL Range 2.5-50 ng/mL

Muscle Skeletal Receptor Tyrosine Kinase (MUSK), Human, ELISA Kit - CSB-E15804h from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 0.39 pg/ml Range 1.56 pg/ml -100 pg/ml

Muscle, skeletal receptor tyrosine-protein kinase, MUSK, Human, ELISA Kit - E0992h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK), Human, ELISA Kit - SEE270Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.054ng/mL Range 0.156-10ng/mL

Muscle, skeletal, receptor tyrosine kinase, Human, ELISA Kit - E01M0028 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Muscle Skeletal Receptor Tyrosine Kinase, MUSK, Human, ELISA Kit - E-EL-H1345 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Muscle Skeletal Receptor Tyrosine Kinase, MUSK, Rabbit, ELISA Kit - E-EL-RB0087 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Muscle Skeletal Receptor Tyrosine Kinase, MUSK, Chicken, ELISA Kit - E-EL-Ch1748 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Muscle Skeletal Receptor Tyrosine Kinase, MUSK, Porcine, ELISA Kit - E-EL-P1300 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Muscle Skeletal Receptor Tyrosine Kinase, MUSK, Monkey, ELISA Kit - E-EL-MK0856 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Muscle, Skeletal, Receptor Tyrosine Kinase, ELISA Kit - MBS054083 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1ng/ml. Range 0.5ng/ml-16ng/ml.

Muscle, Skeletal, Receptor Tyrosine Kinase, ELISA Kit - MBS076372 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human MUSK(Muscle Skeletal Receptor Tyrosine Kinase) ELISA Kit - E-EL-H1345 from Elabscience Category ELISA Kit Sensitivity 0.10 ng/mL Range 0.16—10 ng/mL

Human MUSK (Muscle Skeletal Receptor Tyrosine Kinase) CLIA Kit - E-CL-H0883 from Elabscience Category CLIA Kit Sensitivity 18.75 pg/mL Range Average Recovery (%)

Muscle, Skeletal, Receptor Tyrosine Kinase, ELISA Kit - MBS063859 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Muscle, Skeletal, Receptor Tyrosine Kinase, ELISA Kit - MBS104569 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Muscle, Skeletal, Receptor Tyrosine Kinase, ELISA Kit - MBS096969 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

muscle, skeletal, receptor tyrosine kinase, ELISA Kit - MBS705494 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human MUSK is typically less than 0.39 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 1.56 pg/ml -100 pg/ml.

Muscle, Skeletal, Receptor Tyrosine Kinase, ELISA Kit - MBS057060 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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